Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia-Evidence from an updated meta-analysis including 35 studies

Table 2 ORs and heterogeneity results for the genetic contrasts of MTHFR A1298C polymorphism for ALL risk

	Genetic model	Studies	I ²,	P, Q Test^a	Fixed-effect	Random-effect
	Genetic model	Studies	(%)	P, Q Test^a	OR	OR
All	Allele contrast	29	63	0.000	0.99(0.94-1.05)	1.01(0.91-1.11)
	Dominant model	29	65	0.000	0.99 (0.92-1.06)	1.02(0.90-1.16)
	Recessive model	29	20	0.171	0.99(0.88-1.12)	1.00(0.86-1.17)
	Additive model	29	41	0.012	0.99(0.87-1.13)	1.01(0.83-1.22)
All in HWE	Allele contrast	27	64	0.000	0.99(0.94-1.05)	1.01(0.91-1.11)
	Dominant model	27	66	0.000	0.99(0.92-1.07)	1.02(0.89-1.17)
	Recessive model	27	26	0.113	0.99(0.87-1.22)	1.00(0.84-1.18)
	Additive model	27	44	0.008	0.99(0.87-1.13)	1.01(0.82-1.24)
Children	Allele contrast	22	64	0.000	1.01(0.95-1.07)	1.04(0.93-1.16)
	Dominant model	22	67	0.000	1.01(0.93-1.09)	1.07(0.92-1.24)
	Recessive model	22	26	0.129	1.00(0.88-1.14)	1.00(0.85-1.18)
	Additive model	22	47	0.008	1.00(0.87-1.15)	1.02(0.83-1.25)
Adults	Allele contrast	5	67	0.016	0.96(0.81-1.14)	0.92(0.67-1.25)
	Dominant model	5	68	0.014	0.97(0.79-1.19)	0.92(0.63-1.33)
	Recessive model	5	41	0.150	0.84(0.50-1.42)	0.85(0.37-1.93)
	Additive model	5	51	0.086	0.84(0.49-1.42)	0.80(0.32-2.01)
East Asians	Allele contrast	7	53	0.046	1.01(0.89-1.15)	1.01(0.82-1.23)
	Dominant model	7	63	0.013	1.01(0.87-1.17)	1.01(0.78-1.31)
	Recessive model	7	0	0.730	1.02(0.70-1.50)	1.07(0.72-1.58)
	Additive model	7	0	0.671	1.03(0.70-1.51)	1.07(0.72-1.59)
Caucasians	Allele contrast	12	62	0.003	0.96(0.89-1.04)	0.98(0.86-1.12)
	Dominant model	12	55	0.011	0.95(0.86-1.04)	0.98(0.83-1.15)
	Recessive model	12	42	0.062	0.97(0.82-1.14)	0.97(0.76-1.25)
	Additive model	12	52	0.019	0.95(0.80-1.12)	0.98(0.73-1.30)

All = all of the studies meet the inclusion criteria; All in HWE = all of the studies meet the inclusion criteria except ones with genotype distribution of the controls deviating from HWE; HWE = Hardy-Weinberg Equilibrium.
^a Q test is to estimate heterogeneity between studies. P < 0.10 indicates significant heterogeneity.

ISSN: 1471-2350