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Table 1 Information on the studies included in the meta-analysis

From: Association between insertion/deletion polymorphism in angiotensin-converting enzyme gene and acute lung injury/acute respiratory distress syndrome: a meta-analysis

Author Year Ethnicity N Age, yrs ± SD or (range) Male sex, n (%) Information Mortality timing
ALI/ARDS Healthy controls Controls ALI/ARDS Healthy controls Controls ALI/ARDS Healthy controls Controls Diagnosis Healthy controls Controls
Marshall 2002 Caucasian 96 1906 262 50.3 (17–91) N.A. 53.6 61 (63.5) N.A. 162 (64.1) ARDS Healthy british men “ICU control”; admitted to ICU for non-ARDS respiratory failure with mechanical ventilation (n=88). “CABG control”; admitted to ICU following CABG, but without respiratory failure (n=174). -
Chan 2005 Chinese 17 326 123 59.1 (24–83) 42.5 36.9 (21–76) 9 (52.9) 172 (52.8%) 58 (47.2) ARDS Healthy individuals under routine health check SARS patients without ARDS -
Jerng 2006 Chinese 101 - 348 60±21 - 62.5 68 (68) - 232 (66.7) ARDS - “At-risk”; admitted to ICU with acute respiratory failure but not ARDS (n=138). “Non-at-risk”; no history of respiratory failure or hospitalization within 6M (n=210). 28 day
Adamzik 2007 German 84 200 - 43±16 N.A. - 43 (51.2) N.A. - ARDS Healthy Caucasian individuals of either sex - 30 day
Villar 2008 Spanish 120 364 92 66 (52–75) (18–75) 71 (58–76) 76 (63.2) N.A. 50 (54.3) ARDS population-based controls Severe septic patients without ARDS but had some degree of repiartory failure. ICU stay
Plunket 2008 Caucasian 13 - 199 7M (1-55M) - N.A. 7 (53.8) - N.A. ARDS - Admitted to ICU for ventilatory and/or inotropic support without ARDS (n=199) -
Lu 2011 Chinese 101 236 408 65.1±16.5 N.A. N.A. 68 (67.3) N.A. N.A. ALI Healthy blood donors Admitted to the hospital over the same period due to other diseases (n=408). 28 day
Number of pooled studies in each phenotype 532 3032 1432           
  1. N.A.: not applicable.
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