Table 1 Information on the studies included in the meta-analysis
Author | Year | Ethnicity | N | Age, yrs ± SD or (range) | Male sex, n (%) | Information | Mortality timing | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALI/ARDS | Healthy controls | Controls | ALI/ARDS | Healthy controls | Controls | ALI/ARDS | Healthy controls | Controls | Diagnosis | Healthy controls | Controls | ||||
Marshall | 2002 | Caucasian | 96 | 1906 | 262 | 50.3 (17–91) | N.A. | 53.6 | 61 (63.5) | N.A. | 162 (64.1) | ARDS | Healthy british men | “ICU control”; admitted to ICU for non-ARDS respiratory failure with mechanical ventilation (n=88). “CABG control”; admitted to ICU following CABG, but without respiratory failure (n=174). | - |
Chan | 2005 | Chinese | 17 | 326 | 123 | 59.1 (24–83) | 42.5 | 36.9 (21–76) | 9 (52.9) | 172 (52.8%) | 58 (47.2) | ARDS | Healthy individuals under routine health check | SARS patients without ARDS | - |
Jerng | 2006 | Chinese | 101 | - | 348 | 60±21 | - | 62.5 | 68 (68) | - | 232 (66.7) | ARDS | - | “At-risk”; admitted to ICU with acute respiratory failure but not ARDS (n=138). “Non-at-risk”; no history of respiratory failure or hospitalization within 6M (n=210). | 28 day |
Adamzik | 2007 | German | 84 | 200 | - | 43±16 | N.A. | - | 43 (51.2) | N.A. | - | ARDS | Healthy Caucasian individuals of either sex | - | 30 day |
Villar | 2008 | Spanish | 120 | 364 | 92 | 66 (52–75) | (18–75) | 71 (58–76) | 76 (63.2) | N.A. | 50 (54.3) | ARDS | population-based controls | Severe septic patients without ARDS but had some degree of repiartory failure. | ICU stay |
Plunket | 2008 | Caucasian | 13 | - | 199 | 7M (1-55M) | - | N.A. | 7 (53.8) | - | N.A. | ARDS | - | Admitted to ICU for ventilatory and/or inotropic support without ARDS (n=199) | - |
Lu | 2011 | Chinese | 101 | 236 | 408 | 65.1±16.5 | N.A. | N.A. | 68 (67.3) | N.A. | N.A. | ALI | Healthy blood donors | Admitted to the hospital over the same period due to other diseases (n=408). | 28 day |
Number of pooled studies in each phenotype | 532 | 3032 | 1432 | ||||||||||||