Polymorphisms in the genes coding for iron binding and transporting proteins are associated with disability, severity, and early progression in multiple sclerosis

Table 6 Clinical finding comparisons between multi-carriers and fully wild-types

	Onset	Duration	EDSS	PI	MSSS
Multi-carriers (n=50)	36.23±9.09 (20–53)	7.83±6.42 (1.0-22)	3.65±2.71 (1.0-9.0)	1.0±1.4 (0.09-4.0)	5.06±2.9 (0.85-9.97)
Fully wild-types (n=47)	33.26±10.39 (16–55)	8.78±5.57 (0.5-24)	2.07±1.5 (1.0-7.5)	0.35±0.45 (0.07-2.24)	2.7±2.12 (0.45.-8.64)
P uncorrected	NS	NS	0.0007	0.006	0.0007
(P corrected)			(0.0035)	(0.03)	(0.0035)

Multi-carriers (patients carrying at least four rare alleles in at least two different genes) and fully wild-types (homozygous patients for the common allele in all the considered genes) are as defined in the Results section. Values shown are mean, standard deviation (SD), and (ranges). NS, not significant.

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