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Table 3 Genotype distributions and related OR values

From: Polymorphisms in the genes coding for iron binding and transporting proteins are associated with disability, severity, and early progression in multiple sclerosis

  FPN1-8CG HFEH63D HFEC282Y HEPC-582AG TFP570S
Genotypes (%) CC CG GG HH HD DD CC CY AA AG GG PP PS SS
All cases (n=414) 244 (58.9) 141 (34.05) 29 (7.0) 288 (69.6) 113 (27.3) 13 (3.15) 401 (96.9) 13 (3.1) 205 (49.5) 175 (42.27) 34 (8.2) 278 (67.15) 122 (29.5) 14 (3.4)
OR (95%CI) 4.38 (1.89-10.1) 1.65 (0.67-4.01) 0.76 (0.36-1.58) 1.45 (0.85-2.5) 1.3 (0.6-2.86)
P uncorrected P<0.0001 (NS) (NS) (NS) (NS)
(P corrected) (P<0.0004)
RR (n=273) 162 (59.3) 92 (33.7) 19 (7.0) 190 (69.6) 77 (28.2) 6 (2.2) 266 (97.4) 7 (2.6) 144 (52.75) 114 (42.0) 15 (5.5) 189 (69.2) 75 (27.5) 9 (3.3)
OR (95%CI) 4.35 (1.8-10.5) 1.1 (0.4-3.32) 0.61 (0.25-1.5) 0.94 (0.49-1.83) 1.25 (0.51-3.05)
P uncorrected P<0.0001 (NS) (NS) (NS) (NS)
(P corrected) (P<0.0004)
PP + SP (n=141) 82 (58.2) 49 (34.7) 10 (7.14) 98 (69.5) 36 (25.5) 7 (4.9) 135 (95.7) 6 (4.3) 61 (43.3) 61 (43.3) 19 (13.5) 89 (63.1) 47 (33.3) 5 (3.5)
OR (95%CI) 4.21 (1.57-11.28) 2.65 (0.94-7.45) 1.04 (0.4-2.69) 2.53 (1.34-4.78) 1.35 (0.46-3.95)
P uncorrected P=0.003 (NS) (NS) P=0.006 (NS)
(P corrected) (P=0.012) (P=0.024)
OR1 (95%CI) 1.02 (0.46-2.26) 2.32 (0.77-7.05) 1.69 (0.56-5.12) 2.68 (1.32-5.45) 1.08 (0.35-3.28)
P uncorrected (NS) (NS) (NS) P=0.009 (NS)
(P corrected) (P=0.036)
Controls (n=414) 278 (67.1) 129 (31.2) 7 (1.7) 305 (73.7) 101 (24.4) 8 (1.9) 397 (95.9) 17 (4.1) 238 (57.5) 152 (36.7) 24 (5.8) 280 (67.6) 123 (29.7) 11 (2.7)
  1. All OR calculations are obtained computing the rare homozygous genotype vs the rest of genotypes comparing cases vs controls. OR1 is referred to the Progressive group in which the reference category is the RR subgroup. Corrected and uncorrected P-values are respectively referred to the presence/absence of Bonferroni correction. NS, not significant.