Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study

Nilsson, Daniel; Andiappan, Anand Kumar; Halldén, Christer; De Yun, Wang; Säll, Torbjörn; Tim, Chew Fook; Cardell, Lars-Olaf

doi:10.1186/1471-2350-13-66

BMC Medical Genetics

Table 3 Association of SNPs in the TLR7-TLR8 region with AR phenotype in the Chinese population

From: Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study

						Association test				Skin prick test
Gene	SNP ID	Position^*	Alleles	MAF^†	HW	Allele M + F	Allele M	Allele F	Genotype	B. tp ^‡	D. pt ^#
TLR7	rs179021	12889763	T/G	0.01	1.0	0.72	0.42	0.62	0.62	0.70	0.12
TLR7	rs179020	12889857	G/A	0.25	0.26	0.65	0.38	0.36	0.56	0.021 (0.32)	0.010 (0.025)
TLR7	rs179019	12889969	C/A	0.25	0.34	0.78	0.36	0.44	0.70	0.022 (0.32)	0.0090 (0.025)
TLR7	rs179016	12894442	G/C	0.12	1.0	0.61	0.62	0.81	0.85	0.094	0.013 (0.025)
TLR7	rs179014	12899765	G/A	0.00	1.0	0.80	-	0.91	0.91	0.091	0.24
TLR7	rs179013	12901471	G/A	0.01	1.0	0.85	0.42	0.76	0.76	0.72	0.14
TLR7	rs179012	12901562	G/A	0.06	1.0	0.66	0.92	0.75	0.95	0.67	0.011 (0.025)
TLR7	rs179011	12901960	G/T	0.01	1.0	0.65	0.42	0.58	0.58	0.73	0.13
TLR7	rs179010	12902885	C/T	0.35	0.18	0.86	0.45	0.52	0.59	0.078	0.0046 (0.025)
TLR7	rs179008	12903659	A/T	0.00	1.0	0.37	-	0.47	0.47	0.76	0.43
TLR7	rs864058	12906030	G/A	0.00	0.0091	0.92	0.57	0.85	0.39	0.28	0.88
TLR7	rs179007	12910322	A/G	0.00	0.0044	0.17	-	0.25	0.55	0.76	0.43
TLR7	rs179006	12910521	G/A	0.00	0.0036	0.17	-	0.25	0.55	0.76	0.43
TLR7	rs2269809	12910619	T/G	0.16	0.20	0.38	0.061	0.97	0.27	0.59	0.18
TLR7	rs5935438	12913022	G/C	0.15	0.017	0.34	0.056	0.92	0.27	0.77	0.26
TLR8	rs178998	12917787	T/C	0.16	0.053	0.18	0.024 (0.072)	0.74	0.34	0.43	0.56
TLR8	rs3788935	12922659	G/A	0.17	0.10	0.27	0.025 (0.072)	0.85	0.80	0.45	0.14
TLR8	rs5741883	12924221	C/T	0.02	0.35	0.66	0.84	0.64	0.39	0.27	0.53
TLR8	rs17256081	12926045	T/C	0.15	0.018	0.20	0.010 (0.072)	0.86	0.54	0.84	0.19
TLR8	rs4830805	12927759	A/G	0.19	0.29	0.42	0.016 (0.072)	0.84	0.74	0.40	0.053
TLR8	rs1548731	12927947	C/T	0.02	0.68	0.33	0.93	0.38	0.26	0.16	0.25
TLR8	rs4830808	12932334	T/C	0.23	0.41	0.16	0.054	0.58	0.85	0.091	0.057
TLR8	rs2407992	12939112	C/G	0.19	0.18	0.023 (0.33)	0.0054 (0.072)	0.30	0.59	0.12	0.45

The Hardy-Weinberg (HW) test uses both cases and controls. Male (M) and female (F) individuals were used separately and combined in the allele tests. The Kruskal-Wallis test is used on skin prick data. P-values are given for the HW and association tests.
^*Position according to NCBI build 37.1.
^†Allele frequency of second allele.
^‡ Blomia tropicalis.
^# Dermatophagoides pteronyssinus.

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ISSN: 1471-2350

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