Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study

Nilsson, Daniel; Andiappan, Anand Kumar; Halldén, Christer; De Yun, Wang; Säll, Torbjörn; Tim, Chew Fook; Cardell, Lars-Olaf

doi:10.1186/1471-2350-13-66

BMC Medical Genetics

Table 1 Association of SNPs in the TLR7-TLR8 region with AR phenotype in the Swedish population

From: Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study

						Association test				Skin prick test
Gene	SNP ID	Position^*	Alleles	MAF^†	HW	Allele M + F	Allele M	Allele F	Genotype	Birch	Timothy grass
TLR7	rs179021	12889763	T/G	0.22	0.25	0.60	0.54	0.82	0.50	0.64	0.061
TLR7	rs179020	12889857	G/A	0.24	0.32	0.40	0.71	0.16	0.36	0.17	0.49
TLR7	rs179019	12889969	C/A	0.24	0.32	0.41	0.69	0.16	0.36	0.17	0.49
TLR7	rs179016	12894442	G/C	0.36	0.52	0.34	0.31	0.69	0.61	0.90	0.14
TLR7	rs179014	12899765	G/A	0.24	0.13	0.58	0.65	0.25	0.45	0.19	0.43
TLR7	rs179013	12901471	G/A	0.22	0.44	0.42	0.50	0.56	0.63	0.42	0.095
TLR7	rs179012	12901562	G/A	0.29	0.98	0.67	0.68	0.84	0.83	0.32	0.28
TLR7	rs179011	12901960	G/T	0.23	0.20	0.41	0.63	0.44	0.57	0.46	0.093
TLR7	rs179010	12902885	C/T	0.31	0.012	0.47	0.95	0.26	0.55	0.97	0.90
TLR7	rs179008	12903659	A/T	0.22	0.16	0.29	0.38	0.47	0.44	0.39	0.11
TLR7	rs864058	12906030	G/A	0.07	0.80	0.37	0.29	0.65	0.56	0.44	0.44
TLR7	rs179007	12910322	A/G	0.23	0.81	0.53	0.50	0.90	0.87	0.20	0.21
TLR7	rs179006	12910521	G/A	0.20	0.61	0.17	0.46	0.30	0.43	0.42	0.22
TLR7	rs2269809	12910619	G/T	0.50	0.057	0.58	0.91	0.40	0.028 (0.064)	0.81	0.054
TLR7	rs5935438	12913022	G/C	0.45	0.21	0.28	0.99	0.22	0.0059 (0.064)	0.81	0.019 (0.051)
TLR8	rs178998	12917787	C/T	0.34	0.045	0.19	0.86	0.080	0.15	0.10	0.23
TLR8	rs3788935	12922659	A/G	0.23	0.53	0.0036 (0.076)	0.36	0.0037 (0.046)	0.012 (0.064)	0.44	0.23
TLR8	rs3761624	12923681	A/G	0.22	0.62	0.0080 (0.076)	0.49	0.0056 (0.046)	0.016 (0.064)	0.40	0.16
TLR8	rs5741883	12924221	C/T	0.25	0.96	0.28	0.96	0.17	0.068	0.67	0.038 (0.054)
TLR8	rs17256081	12926045	T/C	0.49	0.11	0.80	0.64	0.98	0.021 (0.064)	0.76	0.0066 (0.035)
TLR8	rs4830805	12927759	G/A	0.21	0.92	0.0069 (0.076)	0.25	0.013 (0.071)	0.042 (0.064)	0.34	0.080
TLR8	rs1548731	12927947	C/T	0.27	0.93	0.50	0.89	0.48	0.046 (0.064)	0.94	0.49
TLR8	rs4830808	12932334	C/T	0.16	0.44	0.70	0.53	0.38	0.55	0.24	0.22
TLR8	rs2407992	12939112	G/C	0.38	0.068	0.63	0.75	0.40	0.67	0.42	0.040 (0.054)

The Hardy-Weinberg (HW) test uses both cases and controls. Male (M) and Female (F) individuals were used separately and combined in the allele tests. The Kruskal-Wallis test is used on skin prick data. P-values are given for the HW and the association tests. Q-values are given in parenthesis.
^*Position according to NCBI build 37.1. ^†Allele frequency of second allele.

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ISSN: 1471-2350

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