Table 5 Significant (Uncorrected) Analyses of SNPs Previously Reported as NTD Risk Factors in this Population

MTHFR rs1801133 677 C > T

0.32

Combined

LR CC Continuous

1.23

1.05

1.45

0.011

Combined

LR CC Recessive

1.26

1.01

1.57

0.041

Combined

LR CC Dominant

1.44

1.04

2.00

0.029

Combined

LR MC Continuous

1.22

1.04

1.43

0.017

Combined

LR MC Recessive

1.25

1.01

1.57

0.045

MTHFD1 rs2236225 R653Q

0.46

Primary

LR MC Continuous

1.35

1.06

1.71

0.014

Primary

LR MC Dominant

1.97

1.28

3.04

0.002

Combined

LR MC Dominant

1.48

1.14

1.92

0.003

Primary

LL Case effect, dominant

0.53

0.30

0.93

0.026

Combined

LL TDT

0.80

0.65

0.99

0.039

Combined

LL Case effect, dominant

0.60

0.42

0.86

0.005

TCblR rs2336573 G220R

0.04

Combined

LR CC Dominant

.^***

0.013