From: Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects
Gene/SNP | TDT | LL CC Rec | LL CC Dom | LR CC Cont | LR CC Rec | LR CC Dom | LL Mat 2DOF | LL Mat Rec | LL Mat Dom | LR MC Cont | LR MC Rec | LR MC Dom |
---|---|---|---|---|---|---|---|---|---|---|---|---|
*MFTC rs17803441 | 0.0300 | 0.1456 | 0.0098 | 0.0003 | 0.0013 | 0.0146 | 0.4634 | 0.6352 | 0.2195 | 0.1928 | 0.2373 | 0.3535 |
CDKN2A rs3218009 | 0.1284 | 0.9996 | 0.1786 | 0.0426 | 0.9775 | 0.1009 | .** | 0.2734 | 0.0004 | 0.3032 | 0.5724 | 0.3296 |
*ADA rs2299686 | 0.8288 | 0.7819 | 0.5289 | 0.2994 | 0.3991 | 0.3958 | 0.2165 | 0.1923 | 0.1183 | 0.0010 | 0.0479 | 0.0005 |
*PEMT rs4646402 | 0.0009 | 0.1861 | 0.0005 | 0.1374 | 0.3728 | 0.1348 | 0.7219 | 0.5709 | 0.7630 | 0.7482 | 0.5319 | 0.9693 |
*MFTC rs3134260 | 0.0225 | 0.1301 | 0.0059 | 0.0006 | 0.0021 | 0.0141 | 0.4213 | 0.4460 | 0.2195 | 0.2102 | 0.2594 | 0.3484 |
*PEMT rs1108579 | 0.0006 | 0.0463 | 0.0014 | 0.0462 | 0.0482 | 0.1846 | 0.7076 | 0.4098 | 0.8059 | 0.9490 | 0.9274 | 0.9873 |
*PEMT rs11656215 | 0.0053 | 0.0008 | 0.3818 | 0.2070 | 0.1461 | 0.5412 | 0.7689 | 0.5639 | 0.8703 | 0.8211 | 0.3273 | 0.5520 |
*CUBN rs7070148 | 0.4864 | 0.4012 | 0.6033 | 0.0909 | 0.8065 | 0.0746 | 0.4458 | 0.4235 | 0.2551 | 0.0010 | 0.1735 | 0.0013 |
*ADA rs406383 | 0.0590 | 0.0311 | 0.3102 | 0.8420 | 0.7244 | 0.6858 | 0.1205 | 0.4468 | 0.0398 | 0.0012 | 0.0021 | 0.0136 |
*GART rs2070388 | 0.0012 | 0.5668 | 0.0012 | 0.0724 | 0.1415 | 0.1209 | 0.4526 | 0.2734 | 0.4332 | 0.5831 | 0.1515 | 0.8478 |
*ADA rs6031682 | 0.5166 | 0.6123 | 0.6101 | 0.0052 | 0.9578 | 0.0016 | 0.8837 | 0.8085 | 0.6321 | 0.0048 | 0.8196 | 0.0019 |
*ADA rs427483 | 0.6597 | 0.8842 | 0.3286 | 0.2509 | 0.1948 | 0.7039 | 0.4568 | 0.3370 | 0.2699 | 0.0018 | 0.0137 | 0.0063 |
DNMT3A rs7560488 | 0.1538 | 0.0021 | 0.6359 | 0.8325 | 0.8348 | 0.8823 | 0.5544 | 0.3633 | 0.3848 | 0.7779 | 0.9764 | 0.6509 |
*CUBN rs2273737 | 0.5067 | 0.7062 | 0.5487 | 0.0780 | 0.3584 | 0.0936 | 0.4034 | 0.4843 | 0.1971 | 0.0021 | 0.2034 | 0.0026 |
MTHFD1 rs2236225 | 0.1505 | 0.9554 | 0.0257 | 0.2570 | 0.3372 | 0.3869 | 0.8915 | 0.6549 | 1.0000 | 0.0139 | 0.2593 | 0.0022 |
*T rs10806845 | 0.2894 | 0.3889 | 0.4518 | 0.0830 | 0.0370 | 0.4302 | 0.2438 | 0.1204 | 0.2378 | 0.0033 | 0.0023 | 0.0701 |
FOLH1 rs383028 | 0.2073 | 0.4975 | 0.2542 | 0.0050 | 0.3617 | 0.0051 | 0.1033 | 1.0000 | 0.0359 | 0.0054 | 0.9171 | 0.0024 |
*CUBN rs1801222 | 1.0000 | 0.5013 | 0.4017 | 0.1514 | 0.7600 | 0.0181 | 0.2822 | 0.1682 | 0.2448 | 0.0091 | 0.1439 | 0.0024 |
*ADA rs6094017 | 0.2199 | 0.6211 | 0.2009 | 0.3960 | 0.8060 | 0.3126 | 0.7449 | 0.5105 | 0.5466 | 0.0026 | 0.0479 | 0.0046 |
*ARID1A rs11247593 | 0.0154 | 0.0502 | 0.0747 | 0.0027 | 0.0090 | 0.0265 | 0.1455 | 0.4060 | 0.1491 | 0.0615 | 0.0458 | 0.5659 |
COMT rs174675 | 0.0795 | 0.7444 | 0.0028 | 0.8722 | 0.5266 | 0.4898 | 0.9321 | 0.7778 | 0.7457 | 0.3665 | 0.2494 | 0.9574 |
*ENOSF1 rs1059384 | 0.6886 | 0.3493 | 0.9141 | 0.0333 | 0.0028 | 0.2734 | 0.9279 | 0.8084 | 0.8226 | 0.0848 | 0.0063 | 0.4655 |
*GART rs4817580 | 0.0029 | 0.9996 | 0.0042 | 0.0849 | 0.9745 | 0.1174 | . | 0.9996 | 0.9223 | 0.4818 | 0.9747 | 0.6024 |
*DNMT3B rs6058896 | 0.0029 | 0.0052 | . | 0.0167 | 0.0244 | 0.9744 | . | 0.2022 | . | 0.0905 | 0.1265 | 0.9744 |
MTHFD1L rs12199063 | 0.2857 | 0.3198 | 0.5830 | 0.1248 | 0.3647 | 0.0575 | 0.0855 | 0.0437 | 0.7457 | 0.0035 | 0.0029 | 0.1898 |
MTHFD1L rs6923486 | 0.1738 | 0.3458 | 0.1249 | 0.1348 | 0.1283 | 0.5396 | 0.2973 | 0.2651 | 0.1785 | 0.0030 | 0.0090 | 0.0348 |
COMT rs737865 | 0.0112 | 0.0149 | 0.1106 | 0.5284 | 0.3462 | 0.2354 | 0.1983 | 0.1326 | 0.1587 | 0.0852 | 0.0031 | 0.5815 |
*MTR rs10925260 | 0.0290 | 0.0031 | 0.9246 | 0.6329 | 0.4355 | 0.8813 | 0.4513 | 0.7071 | 0.2073 | 0.1865 | 0.2408 | 0.3423 |
*ADA rs452159 | 0.0577 | 0.5282 | 0.0047 | 0.7260 | 0.9583 | 0.4298 | 0.1675 | 0.0627 | 0.3633 | 0.0059 | 0.0578 | 0.0032 |
TFAP2A rs17635655 | 0.8108 | 0.6367 | 0.7196 | 0.0116 | 0.0236 | 0.0813 | 0.1688 | 0.0876 | 0.8527 | 0.0037 | 0.0075 | 0.0645 |
CUBN rs11591606 | 0.1808 | 0.2426 | 0.4253 | 0.4459 | 0.6193 | 0.2639 | 0.8403 | 0.6321 | 0.6380 | 0.3280 | 0.9827 | 0.0058 |
MTHFD1L rs2295083 | 0.6044 | 0.2928 | 0.2330 | 0.0168 | 0.0038 | 0.7292 | 0.2734 | 0.1752 | 0.5943 | 0.0558 | 0.0342 | 0.7136 |
*PEMT rs16961845 | 0.5691 | 0.4101 | 0.2719 | 0.4982 | 0.4864 | 0.9363 | . | 0.0082 | . | 0.0072 | 0.0048 | 0.9255 |
*ALDH1A2 rs7169289 | 0.1063 | 0.6803 | 0.0967 | 0.0214 | 0.5178 | 0.0043 | 0.4346 | 0.2067 | 0.6266 | 0.0633 | 0.6737 | 0.0513 |
*MTR rs10733117 | 0.0099 | 0.4520 | 0.0043 | 0.6020 | 0.7559 | 0.6099 | 0.2998 | 0.1791 | 0.2388 | 0.1436 | 0.3788 | 0.1542 |
MTHFD1L rs17080476 | 0.0233 | 0.9996 | 0.0949 | 0.0070 | 0.0244 | 0.0320 | . | 0.5299 | 0.9136 | 0.1357 | 0.0994 | 0.2676 |
MAT2B rs17535909 | 0.0102 | 0.0045 | 0.5083 | 0.2745 | 0.1949 | 0.7860 | 0.2061 | 0.3321 | 0.2406 | 0.8030 | 0.6685 | 0.8863 |
GNMT rs9462856 | 0.0601 | 0.9187 | 0.0048 | 0.7463 | 0.7773 | 0.3914 | 0.8419 | 0.5788 | 1.0000 | 0.6497 | 0.8424 | 0.5744 |
*CTH rs12733999 | 0.1546 | 0.1603 | 0.7406 | 0.0051 | 0.0048 | 0.6384 | . | 0.1477 | 0.3414 | 0.0167 | 0.0285 | 0.1264 |
CDKN2A rs7041637 | 0.4033 | 0.0881 | 0.3011 | 0.0048 | 0.0067 | 0.1269 | 0.3323 | 0.2793 | 0.1978 | 0.1369 | 0.3445 | 0.0716 |
*RAI1 rs9914733 | 0.2215 | 0.1984 | 0.4266 | 0.8834 | 0.4610 | 0.6300 | 0.0980 | 0.6952 | 0.0320 | 0.0133 | 0.8111 | 0.0049 |
*FTCD rs2839127 | 0.2296 | 0.0301 | 0.7043 | 0.8551 | 0.2725 | 0.8462 | 0.0195 | 0.2266 | 0.0053 | 0.1576 | 0.0483 | 0.3997 |
PDGFRA rs9993187 | 0.3615 | 0.0802 | 0.7374 | 0.0639 | 0.1576 | 0.0123 | 0.4850 | 0.4235 | 0.2999 | 0.0083 | 0.8603 | 0.0054 |
MTHFD1L rs4869987 | 0.1603 | 0.6351 | 0.0458 | 0.1693 | 0.2368 | 0.2939 | 0.0284 | 0.3579 | 0.0511 | 0.0167 | 0.1767 | 0.0061 |
*ARID1A rs11247594 | 0.0376 | 0.0989 | 0.1141 | 0.0059 | 0.0159 | 0.0438 | 0.2152 | 0.2972 | 0.3060 | 0.0758 | 0.0601 | 0.5558 |
*ARID1A rs11247596 | 0.0059 | 0.1178 | 0.0151 | 0.0570 | 0.2900 | 0.0682 | 0.6110 | 0.3713 | 0.8781 | 0.5223 | 0.0978 | 0.9777 |
FOLH1 rs16906205 | 0.2509 | 0.5003 | 0.3078 | 0.0993 | 0.9856 | 0.0730 | . | 0.9996 | 0.0060 | 0.0160 | 0.9856 | 0.0102 |
*FTCD rs7280485 | 0.5455 | 1.0000 | 0.2928 | 0.9719 | 0.9612 | 1.0000 | 0.0402 | 0.2205 | 0.0796 | 0.1847 | 0.9315 | 0.0062 |
ENOSF1 rs10502289 | 0.4050 | 0.0606 | 0.9176 | 0.2608 | 0.0084 | 0.8743 | 0.9012 | 0.6553 | 0.8231 | 0.7398 | 0.4196 | 0.9254 |
*MFTC rs10112450 | 0.0065 | 0.0154 | 0.1380 | 0.1077 | 0.0765 | 0.7454 | 0.4967 | 0.2680 | 0.4937 | 0.5459 | 0.7307 | 0.3836 |
*MFTC rs1865855 | 0.0339 | 0.2226 | 0.0596 | 0.0066 | 0.2347 | 0.0091 | 0.4858 | 0.3270 | 0.3615 | 0.3489 | 0.3248 | 0.2103 |
MTHFD1 rs11627525 | 0.7010 | 0.9468 | . | 0.7285 | 0.5723 | 0.9802 | . | 0.0067 | 1.0000 | 0.5750 | 0.9194 | 0.1216 |
GGH rs11988534 | 0.0409 | 0.0067 | 0.6955 | 0.2427 | 0.1156 | 0.8060 | 0.6044 | 0.6257 | 0.4665 | 0.9112 | 0.8775 | 0.5796 |
MTHFR rs17037425 | 1.0000 | 0.8419 | 0.6233 | 0.4158 | 0.2803 | 0.6769 | 0.0149 | 0.0068 | 0.7817 | 0.1828 | 0.0796 | 0.4756 |
MTHFD1L rs487637 | 0.1946 | 0.4121 | 0.0364 | 0.0162 | 0.5831 | 0.0069 | 0.8861 | 0.7152 | 0.8488 | 0.2125 | 0.5912 | 0.2003 |
DMGDH rs663646 | 0.2749 | 0.0070 | 0.8907 | 0.7786 | 0.1838 | 0.7429 | 0.8537 | 0.5782 | 0.9263 | 0.5080 | 0.1877 | 0.8789 |
NNMT rs10400393 | 0.0074 | 0.1090 | 0.0203 | 0.8395 | 0.6189 | 0.9926 | 0.9369 | 0.7317 | 1.0000 | 0.5062 | 0.4840 | 0.6355 |
*CUBN rs11254375 | 0.3772 | 0.5709 | 0.4612 | 0.6008 | 0.1449 | 0.7839 | 0.0331 | 0.6321 | 0.0097 | 0.0274 | 0.0074 | 0.2404 |
MTHFD1L rs11155772 | 0.1876 | 0.1492 | 0.8084 | 0.5140 | 0.8021 | 0.2358 | 0.2306 | 0.0932 | 1.0000 | 0.0126 | 0.0075 | 0.5404 |
ALDH1A2 rs6493978 | 0.5450 | 0.0984 | 0.5323 | 0.1136 | 0.6939 | 0.0308 | 0.9785 | 0.9093 | 0.8399 | 0.0333 | 0.4523 | 0.0076 |
RAI1 rs11658846 | 0.2504 | 1.0000 | 0.2329 | 0.1382 | 0.6534 | 0.1409 | 0.3954 | 0.9994 | 0.1351 | 0.0104 | 0.6431 | 0.0088 |
LRP2 rs3914468 | 0.8840 | 0.1061 | 0.1878 | 0.2044 | 0.0181 | 0.7696 | 0.1386 | 0.7577 | 0.0734 | 0.2555 | 0.0080 | 0.9562 |
PDGFRA rs2114039 | 0.0081 | 0.1297 | 0.0185 | 0.9479 | 1.0000 | 0.9317 | 0.7483 | 0.4513 | 0.9146 | 0.5652 | 0.7360 | 0.5786 |
MTHFR rs17367504 | 0.7868 | 0.3302 | 0.9193 | 0.7251 | 0.6814 | 0.5857 | 0.0174 | 0.7817 | 0.0081 | 0.2908 | 0.4835 | 0.1536 |
*EHMT1 rs7039441 | 0.4612 | 0.3106 | 0.8211 | 0.9611 | 0.8037 | 0.9150 | 0.0319 | 0.2588 | 0.0090 | 0.0981 | 0.8608 | 0.0282 |
*MFTC rs750606 | 0.0378 | 0.7460 | 0.0220 | 0.0091 | 0.3426 | 0.0090 | 0.2301 | 0.0994 | 0.3619 | 0.3230 | 0.3719 | 0.1578 |
MTHFD1L rs12524884 | 0.6841 | 0.7842 | 0.6630 | 0.2910 | 0.5126 | 0.1146 | 0.2320 | 0.0876 | 0.7633 | 0.0094 | 0.0142 | 0.1789 |
*RAI1 rs11654526 | 0.1373 | 0.0904 | 0.3348 | 0.9082 | 0.6677 | 0.7709 | 0.1313 | 0.4417 | 0.0450 | 0.0099 | 0.2692 | 0.0106 |