Table 2 SNPs Selected for Study in the Combined NTD Cohort

rs2428735

PADI4

0.0006

0.2801

0.0229

0.4043

rs942459

PADI4

0.0089

0.3841

0.1002

.^*

rs12743862

ARID1A

0.1030

0.0314

0.9124

.

rs12729444

ARID1A

0.1068

0.0314

0.9124

.

rs12726081

ARID1A

0.1030

0.0314

0.9124

.

rs12726287

ARID1A

0.1030

0.0314

0.9276

.

rs11247593

ARID1A

0.0208

0.1294

0.1815

0.1383

rs11247594

ARID1A

0.0257

0.1580

0.2126

0.1331

rs12752833

ARID1A

0.1030

0.0314

0.9124

.

rs12735646

ARID1A

0.1030

0.0290

0.9124

.

rs12737946

ARID1A

0.1030

0.0314

0.9124

.

rs12731749

ARID1A

0.0862

0.0201

0.8813

.

rs11247596

ARID1A

0.7022

0.0311

0.9123

0.9708

rs12733999

CTH

0.0277

1.0000

0.0077

.

rs10889869

CTH

0.9408

0.0436

0.2582

0.9918

rs12723350

CTH

0.0472

0.6803

0.0120

0.0572

rs16834388

MTR

0.1070

0.0225

0.9177

0.8117

rs10733117

MTR

0.1604

0.0207

0.5363

0.1956

rs10925238

MTR

0.0503

0.0139

0.9512

0.5724

rs4077829

MTR

0.0921

0.0170

0.7931

0.6494

rs12060570

MTR

0.0602

0.0201

0.9373

0.6843

rs2789352

MTR

0.2535

0.0348

0.7505

0.1245

rs7367859

MTR

0.2355

0.0444

0.5437

0.0571

rs10925260

MTR

0.1262

0.0328

0.8485

0.1713

rs2853522

MTR

0.1080

0.0449

0.8826

0.1600

rs2853523

MTR

0.2127

0.0418

0.7770

0.0594

rs3944004

LRP2

0.3963

0.0048

0.5667

0.2170

rs4667593

LRP2

0.7913

0.0087

0.3028

0.7203

rs16856530

LRP2

0.1458

0.4352

0.0396

0.7874

rs2024481

LRP2

0.9568

0.0087

0.2889

0.7601

rs10490131

LRP2

0.4348

0.0140

0.8093

0.8201

rs4668123

LRP2

0.1564

0.9379

0.0487

0.9494

rs2268373

LRP2

0.0338

0.0229

0.0718

0.4172

rs11886219

LRP2

0.0491

0.3924

0.0034

.

rs2268365

LRP2

0.6858

0.0312

0.6914

0.8866

rs2673164

LRP2

0.5967

0.7656

0.4009

0.0231

rs700550

LRP2

0.4767

0.2507

0.7529

0.0383

rs853988

LRP2

0.8386

0.6872

0.2807

0.0048

rs2673177

LRP2

0.0095

0.5791

0.0015

0.0279

rs10199676

LRP2

0.0075

0.7290

0.0213

0.9036

rs2389557

LRP2

0.0336

0.6507

0.1005

0.4636

rs16856843

LRP2

0.0075

0.9055

0.0133

0.9035

rs10806845

T (Brachyury)

0.0399

0.6331

0.0010

0.3100

rs3127441

T (Brachyury)

0.0485

0.6215

0.0043

0.8873

rs12200529

T (Brachyury)

0.5867

0.7758

0.0278

0.2407

rs16898752

T (Brachyury)

0.1443

1.0000

0.0412

0.2063

rs7753771

T (Brachyury)

0.5378

1.0000

0.0384

.

rs1001978

T (Brachyury)

0.5378

1.0000

0.0384

.

rs3099280

T (Brachyury)

0.9972

0.5149

0.0199

0.1406

rs4512347

MFTC

0.0344

0.6473

0.2789

.

rs10112450

MFTC

0.1575

0.0196

0.4726

0.3474

rs17803441

MFTC

0.0016

0.0115

0.2911

0.2838

rs3134260

MFTC

0.0016

0.0086

0.2513

0.2919

rs4876902

EHMT1

0.4872

0.0595

0.6710

0.9049

rs4526432

EHMT1

0.0433

0.0251

0.5323

0.4040

rs10752062

CUBN

0.2564

0.8216

0.0254

0.1471

rs17139378

CUBN

0.2113

0.6780

0.0086

0.1051

rs7100290

CUBN

0.4039

0.0269

0.6692

.

rs1276720

CUBN

0.2147

0.0422

0.5445

0.0714

rs1276721

CUBN

0.1737

0.0206

0.5381

0.2471

rs11254284

CUBN

0.4198

0.7175

0.0474

0.0548

rs11254313

CUBN

0.4354

0.4206

0.0277

0.3041

rs12258009

CUBN

0.7700

0.1582

0.6214

0.7119

rs17431655

CUBN

0.1453

0.8474

0.0459

.

rs17139663

CUBN

0.0407

0.8864

0.0579

0.5552

rs11254339

CUBN

0.0490

0.7928

0.0838

0.8621

rs1801228

CUBN

0.1118

0.8474

0.0356

.

rs12254816

CUBN

0.5285

0.6670

0.0407

0.1765

rs7899751

CUBN

0.4747

0.8386

0.0433

0.1183

rs11254375

CUBN

0.7142

0.6682

0.5854

0.0332

rs7070148

CUBN

0.1447

0.9013

0.0029

0.2028

rs2273737

CUBN

0.1136

0.9042

0.0064

0.3337

rs7096079

CUBN

0.0202

0.8897

0.0432

0.3447

rs2073588

FTH1

0.2129

0.0046

0.9390

.

rs17156616

FTH1

0.5455

0.0127

0.8668

.

rs195445

FTH1

0.9840

0.3738

0.8436

0.7908

rs7957531

LRP6

0.4835

0.9068

0.0407

0.2288

rs10845493

LRP6

0.1614

0.0149

0.9106

0.7491

rs17302049

LRP6

0.4464

0.0242

0.8904

0.9593

rs1181334

LRP6

0.2935

0.0211

0.9466

0.9000

rs12309338

LRP6

0.7156

0.6056

0.0329

.

rs3760183

PEMT

0.0146

0.0111

0.2960

.

rs16961845

PEMT

0.2442

0.8788

0.0043

.

rs4646342

PEMT

0.4687

0.6714

0.7126

0.0351

rs2350631

PEMT

0.0641

0.6803

0.0181

0.3410

rs9910090

SHMT1

0.0342

0.1508

0.1370

0.7042

rs9901160

SHMT1

0.5153

0.0153

0.9278

0.4380

rs4911263

DNMT3B

0.0686

0.8332

0.0145

0.0475

rs6058896

DNMT3B

0.0460

0.0016

0.5438

.

rs447833

ADA

0.0832

0.0090

0.3777

0.6497

rs2299686

ADA

0.4258

0.7269

0.0391

0.2794

rs427483

ADA

0.3645

0.5276

0.0275

0.5681

rs6094017

ADA

0.1869

0.5169

0.0088

0.6004