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Table 6 Risk of rs2275913 and rs3748067 for gene methylations

From: Influence of IL17A polymorphisms on the aberrant methylation of DAPK and CDH1 in non-cancerous gastric mucosa

CIHM (DAPKorCDH1)

 over all

HR

LR

unknown

HR vs. LR; OR (95%CI)

p value

 unmethylated (153)

76

77

0

reference

-

methylated (248)

144

101

3

1.45 (0.955-2.20)

0.081

 60 = <

     

 unmethylated (83)

38

45

0

reference

-

 methylated (143)

89

54

0

1.93 (1.10-3.39)

0.023

DAPK

     

 over all

HR

LR

unknown

HR vs. LR; OR (95%CI)

p value

 unmethylated (205)

102

102

1

reference

-

methylated (196)

118

76

2

1.57 (1.04-2.35)

0.031

 60 = <

     

 unmethylated (103)

49

54

0

reference

-

 methylated (123)

78

45

0

1.91 (1.10-3.30)

0.021

CDH1

     

 over all

HR

LR

unknown

HR vs. LR; OR (95%CI)

p value

 unmethylated (252)

134

116

2

reference

-

methylated (149)

86

62

1

1.20 (0.787-1.83)

0.40

 60 = <

     

 unmethylated (145)

73

72

0

reference

-

 methylated (81)

54

27

0

2.01 (1.12-3.62)

0.020

DAPK and CDH1

     

 over all

HR

LR

unknown

HR vs. LR; OR (95%CI)

p value

unmethylated (304)

160

141

3

reference

-

 methylated (97)

60

37

0

1.44 (0.890-2.34)

0.14

 60 = <

     

 unmethylated (165)

84

81

0

reference

-

 methylated (61)

43

18

0

2.42 (1.25-4.68)

0.0087

  1. HR: -197 A carrier with*1249 CC genotype, LR: the others by logistic regression analysis after adjustment for age, gender and H. pylori infection status.
  2. ( ): number of subjects.