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Table 4 Hazard ratio and 95% CI for different cardiovascular events conferred by the  RNLS rs2576178  A > G and  rs2296545 C > G  polymorphisms tested by COX regression according to different genetic model in MDC-CVA

From: The Renalase Asp37Glu polymorphism is not associated with hypertension and cardiovascular events in an urban-based prospective cohort: the Malmö Diet and cancer study

  Genetic model
  Additive p-value Autosomal recessive p-value Autosomal dominant p-value
     RNLS rs2576178    
Coronary events* 0.963 (0.826-1.123) 0.63 0.791 (0.532-1.177) 0.25 1.001 (0.824-1.217) 0.99
Coronary events† 0.977 (0.820-1.163) 0.79 0.798 (0.507-1.256) 0.33 1.021 (0.819-1.275) 0.85
Stroke* 0.909 (0.764-1.082) 0.28 0.867 (0.567-1.324) 0.51 0.893 (0.717-1.111) 0.31
Stroke† 0.866 (0.710-1.056) 0.16 0.663 (0.387-1.137) 0.13 0.881 (0.689-1.127) 0.31
Heart failure events* 1.014 (0.808-1.273) 0.90 0.887 (0.504-1.660) 0.68 1.059 (0.791-1.417) 0.70
Heart failure events† 1.033 (0.800-1.335) 0.80 0.801 (0.408-1.575) 0.52 1.117 (0.805-1.550) 0.51
Atrial fibrillation/flutter events* 0.874 (0.746-1.024) 0.09 0.852 (0.581-1.225) 0.41 0.843 (0.692-1.027) 0.09
Atrial fibrillation/flutter events† 0.843 (0.706-1.006) 0.06 0.859 (0.562-1.313) 0.48 0.795 (0.638-0.990) 0.04
     RNLS  rs2296545    
Coronary events* 0.933 (0.812-1.073) 0.32 0.843 (0.653-1.089) 0.19 0.964 (0.780-1.193) 0.74
Coronary events† 0.888 (0.757-1.042) 0.15 0.727 (0.536-0.987) 0.04 0.949 (0.745-1.209) 0.67
Stroke* 1.040 (0.892-1.213) 0.62 0.982 (0.749-1.287) 0.89 1.115 (0.876-1.421) 0.38
Stroke† 1.128 (0.948-1.342) 0.18 1.115 (0.831-1.497) 0.47 1.229 (0.928-1.626) 0.15
Heart failure events* 0.971 (0.789-1.195) 0.78 0.936 (0.647-1.354) 0.72 0.981 (0.714-1.348) 0.98
Heart failure events† 0.976 (0.771-1.236) 0.84 0.896 (0.643-1.472) 0.90 0.965 (0.674-1.381) 0.85
Atrial fibrillation/flutter events* 1.030 (0.897-1.184) 0.67 1.079 (0.851-1.369) 0.53 1.011 (0.815-1.253) 0.92
Atrial fibrillation/flutter events† 1.051 (0.901-1.226) 0.53 1.113 (0.856-1.446) 0.42 1.033 (0.814-1.312 0.79
  1. *Adjustment for age, sex; † adjustment for hypertension, diabetes mellitus, smoking habit, previous CV event, hypercholesterolemia.