Table 4 Hazard ratio and 95% CI for different cardiovascular events conferred by the  RNLS rs2576178  A > G and  rs2296545 C > G  polymorphisms tested by COX regression according to different genetic model in MDC-CVA

Coronary events*

0.963 (0.826-1.123)

0.63

0.791 (0.532-1.177)

0.25

1.001 (0.824-1.217)

0.99

Coronary events†

0.977 (0.820-1.163)

0.79

0.798 (0.507-1.256)

0.33

1.021 (0.819-1.275)

0.85

Stroke*

0.909 (0.764-1.082)

0.28

0.867 (0.567-1.324)

0.51

0.893 (0.717-1.111)

0.31

Stroke†

0.866 (0.710-1.056)

0.16

0.663 (0.387-1.137)

0.13

0.881 (0.689-1.127)

0.31

Heart failure events*

1.014 (0.808-1.273)

0.90

0.887 (0.504-1.660)

0.68

1.059 (0.791-1.417)

0.70

Heart failure events†

1.033 (0.800-1.335)

0.80

0.801 (0.408-1.575)

0.52

1.117 (0.805-1.550)

0.51

Atrial fibrillation/flutter events*

0.874 (0.746-1.024)

0.09

0.852 (0.581-1.225)

0.41

0.843 (0.692-1.027)

0.09

Atrial fibrillation/flutter events†

0.843 (0.706-1.006)

0.06

0.859 (0.562-1.313)

0.48

0.795 (0.638-0.990)

0.04

 RNLS  rs2296545

Coronary events*

0.933 (0.812-1.073)

0.32

0.843 (0.653-1.089)

0.19

0.964 (0.780-1.193)

0.74

Coronary events†

0.888 (0.757-1.042)

0.15

0.727 (0.536-0.987)

0.04

0.949 (0.745-1.209)

0.67

Stroke*

1.040 (0.892-1.213)

0.62

0.982 (0.749-1.287)

0.89

1.115 (0.876-1.421)

0.38

Stroke†

1.128 (0.948-1.342)

0.18

1.115 (0.831-1.497)

0.47

1.229 (0.928-1.626)

0.15

Heart failure events*

0.971 (0.789-1.195)

0.78

0.936 (0.647-1.354)

0.72

0.981 (0.714-1.348)

0.98

Heart failure events†

0.976 (0.771-1.236)

0.84

0.896 (0.643-1.472)

0.90

0.965 (0.674-1.381)

0.85

Atrial fibrillation/flutter events*

1.030 (0.897-1.184)

0.67

1.079 (0.851-1.369)

0.53

1.011 (0.815-1.253)

0.92

Atrial fibrillation/flutter events†

1.051 (0.901-1.226)

0.53

1.113 (0.856-1.446)

0.42

1.033 (0.814-1.312

0.79