Skip to main content

Table 3 Association between  RNLS rs2576178  A > G and  rs2296545 C > G  polymorphisms and BP according to different genetic models

From: The Renalase Asp37Glu polymorphism is not associated with hypertension and cardiovascular events in an urban-based prospective cohort: the Malmö Diet and cancer study

     RNLS rs2576178    
    Genetic model    
Type of blood pressure adjustment for AHT Additive p-value Autosomal recessive p-value Autosomal dominant p-value
Crude (non adjusted)       
SBP (mmHg) −0.311 (0.365) 0.39 0.552 (0.863) 0.52 −0.669 (0.467) 0.15
DBP (mmHg) 0.074 (0.187) 0.69 0.491 (0.442) 0.27 −0.023 (0.239) 0.92
Fixed addition       
SBP (mmHg) −0.254 (0.386) 0.51 0.492 (0.913) 0.59 −0.558 (0.494) 0.26
DBP (mmHg) 0.102 (0.198) 0.60 0.461 (0.467) 0.32 0.032 (0.253) 0.90
Stepped addition       
SBP (mmHg) −0.297 (0.387) 0.44 0.477 (0.915) 0.60 −0.625 (0.495) 0.21
DBP (mmHg) 0.065 (0.202) 0.75 0.429 (0.478) 0.37 −0.019 (0.259) 0.94
     RNLS  rs2296545    
Type of blood pressure adjustment for AHT Additive p-value Autosomal recessive p-value Autosomal dominant p-value
Crude (non adjusted)       
SBP (mmHg) 0.075 (0.332) 0.82 0.336 (0.575) 0.56 −0.087 (0.513) 0.87
DBP (mmHg) −0.118 (0.170) 0.49 −0.143 (0.294) 0.63 −0.168 (0.262) 0.52
Fixed addition       
SBP (mmHg) −0.022 (0.351) 0.95 0.249 (0.609) 0.68 −0.251 (0.543) 0.64
DBP (mmHg) −0.167 (0.179) 0.35 −0.187 (0.311) 0.55 −0.250 (0.277) 0.37
Stepped addition       
SBP (mmHg) 0.033 (0.352) 0.93 0.336 (0.610 0.58 −0.188 (0.544) 0.73
DBP (mmHg) −0.124 (0.183) 0.50 −0.099 (0.318) 0.76 −0.217 (0.284) 0.44
  1. Adjustment for age, sex, BMI.