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Table 1 Study population and clinical covariates

From: SNP-set analysis replicates acute lung injury genetic risk factors

Variable

ALI (n = 142)

Non-ALI (n = 325)

p-value

Age, years

39 ± 19

37 ± 18

0.35

Male, n (%)

115 (81%)

249 (77%)

0.30

African ancestry, n (%)

61 (43%)

161 (48%)

0.29

European ancestry, n (%)

74 (51%)

150 (43%)

0.14

Era of injury 1999 – 2003, n (%)

85 (60%)

160 (49%)

0.07

Injury Factors

Blunt trauma, n (%)

101 (71%)

218 (67%)

0.39

ISS

26 ± 8

24 ± 7

0.008

APACHE III †

64 ± 24

58 ± 18

0.004

Pulmonary contusion, n (%)

54 (38%)

76 (24%)

0.0013

Treatment Factors

Total PRBC 1st 24 h, units (Range)

3.16 (0 – 19)

1.56 (0 – 27)

<0.001

Mechanical ventilation, n (%)

142 (100%)

238 (73%)

<0.001

Outcomes

Mortality, n (%)

35 (25%)

24 (7%)

<0.001

Hospital length of stay, days

22 (11 – 36)

13 (8 – 26)

<0.001

  1. Most continuous variables are presented as mean ± standard deviation, and categorical variables are shown as number (n) and percentage of total population. Hospital length of stay is displayed as median (interquartile range) due to a skewed distribution. ISS: injury severity scale; APACHE III †: Acute physiology and chronic health evaluation, modified to omit the arterial blood gas oxygenation criterion given its collinearity with ALI; PRBC: packed red blood cell transfusion. Blunt trauma is opposed to penetrating trauma. Statistics shown reflect the results of binomial testing, Student’s T test, or nonparametric testing (Wilcoxon rank sum) as appropriate given the data distributions.