Figure 3

LD plots for European ancestry (AA) trauma subjects for 2 genes with positive ALI associations. Plots for the genes VEGFA (A) and NFKBIA (B) are shown. Grayscale reflects the pairwise LD as measured by r², with high LD in black and low/absent LD in white. As in Figure 2, previously reported ALI – associated SNPs are circled (red) and the yellow lines outline the haplotypes detected by kernel function(s) as being associated with ALI. Whereas the block detected in VEGFA is defined by the previously reported SNP rs3025039, the association with NFKBIA does not overlap the previously reported NFKBIA ALI – associated locus.