Skip to main content

Table 1 Distribution of Selected Characteristics and ESR1 Polymorphisms in Participants

From: Estrogen receptor alpha gene polymorphisms and risk of HBV-related acute liver failure in the Chinese population

Characteristic

ASC

HBV-ALF

P value

(n =857)

(n = 359)

Gender, no. (%)

  Men

510 (59.5)

298 (83.0)

 

  Women

347 (40.5)

61(17.0)

<0.001

Age (years), mean (SD)

36.6 ± 11.3

41.1 ± 12.7

<0.001

Alcohol drinkers, no. (%)

160(18.7)

121 (33.7)

<0.001

HBeAg positive, no (%)

298(34.8)

107(29.8)

0.094

TBil (μmol/L)

13.4 ± 4.3

321.1 ± 166.1

 

ALT (IU/L)

27.9 ± 10.7

410.1 ± 541.6

 

c.453-397 T > C (rs2234693)

TT, no. (%)

330(38.4)

109(30.4)

 

TC, no. (%)

424(49.6)

182(50.7)

 

CC, no. (%)

103(12.0)

68(18.9)

 

T allele, no. (%)

1086(62.4)

400 (55.7)

 

C allele, no. (%)

632(36.9)

318 (44.3)

5.37 × 10-4

c.30 T > C (rs2077647)

TT, no. (%)

418(48.8)

143 (39.8)

 

TC, no. (%)

348(40.6)

160 (44.7)

 

CC, no. (%)

91 (10.6)

56 (15.6)

 

T allele, no. (%)

1184(69.1)

446 (62.1)

 

C allele, no. (%)

530 (30.9)

272 (37.9)

8.65 × 10-4

  1. Notes: “Drinker” was defined as alcohol consumption of ≥40 g/week for men and ≥20 g/week for women, which included occasional drinkers and daily drinkers. The genotype distributions of SNPs in each group were in Hardy–Weinberg equilibrium. P values were given for the comparison between ASC and HBV-ALF groups by χ 2 tests. TBil, total bilirubin; ASC, asymptomatic HBV carriers; HBV-ALF, patients with HBV-related acute liver failure.