Figure 1

Multipoint HLODs using the GWS marker set and the two-liability class parametric model: a) using all families, b) in the subset of families with 2–3 affected males and possible male-to-male transmission of prostate cancer, c) in the subset of families that were not included in the original HPCX linkage paper [3, 38] with 2–3 affected males and possible male-to-male transmission of prostate cancer, d) in the subset of families with 2–3 affected males that also meet the Carter criteria, e) in the subset of families with 2–3 affected males that also meet the Carter criteria and were not included in the original HPCX linkage paper [38]. Panel f is from the UCSC Genome Browser (http://genome.ucsc.edu) on the Human February 2009 (GRCh37/hg19) Assembly of the human genome and shows the 2-LOD drop linkage interval from the HLOD graph in panel c. This region extends from approximately 122 cM to 144 cM, bounded by markers GATA165B12 and DXS1232, spanning base pair positions 120877968 to 139280361.