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Table 2 Genotype and allele frequencies of the CYP P450 genes in breast cancer patients

From: Association of cytochrome P450 genetic polymorphisms with neoadjuvant chemotherapy efficacy in breast cancer patients

Nomenclature

rs

Nucleotide changes

Effect

n

Genotype frequencies, %

Allele frequencies, %

wt

ht

vt

p

q

 CYP2C8*2 

rs11572103

T805A

I269F

383

99.22

0.78

0.00

99.61

0.39

 CYP2C8*3 

rs11572080+ rs10509681

G416A+ A1196G

R139K + K399R

390

83.85

15.64

0.51

91.67

8.33

 CYP2C9*2 

rs1799853

C430T

R144C

391

79.54

20.20

0.26

89.64

10.36

 CYP2C9*3 

rs1057910

A1075C

I359L

394

81.22

17.77

1.02

90.10

9.90

 CYP2C19*2 

rs4244285

G681A

Splicing defect

393

58.52

39.19

2.29

78.12

21.88

 CYP2C19*3 

rs4986893

G636A

W212X

388

97.94

2.06

0.00

98.97

1.03

 CYP3A4*1B 

rs2740574

A-392 G

5'NTO change

389

94.86

5.14

0.00

97.43

2.57

 CYP3A4*2 

rs55785340

T664C

S222P

391

100.00

0.00

0.00

100.00

0.00

 CYP3A5*3 

rs776746

A6986G

R487C

392

0.26

11.99

87.76

6.25

93.75

 CYP2B6*5 

rs3211371

C1459T

Splicing defect

390

85.64

12.56

1.79

91.92

8.08