| +45 T > G | +276 G > T | −11377 C > G | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. studies | Sample size | Per allele risk | I2% | No. studies | Sample size | Per allele risk | I2% | No. studies | Sample size | Per allele risk | I2% | ||||
Case/control | OR(95%CI) | P | Case/control | OR(95%CI) | P | Case/control | OR(95%CI) | P | |||||||
Overall | 24 | 6398/10829 | 1.22(1.07-1.39) | 0.004 | 74.2 | 27 | 8392/18730 | 0.90(0.83-0.97) | 0.007 | 58.0 | 20 | 7835/14023 | 1.09(1.01-1.17) | 0.032 | 53.6 |
CHD | 17 | 4685/5881 | 1.29(1.09-1.52) | 0.004 | 76.9 | 18 | 6585/7760 | 0.89(0.81-0.99) | 0.025 | 65.1 | 11 | 5687/7431 | 1.09(0.99-1.19) | 0.090 | 51.8 |
Population | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
European origin | 12 | 3751/8269 | 1.10(0.94-1.27) | 0.226 | 63.1 | 15 | 6306/11254 | 0.95(0.89-1.02) | 0.155 | 33.8 | 14 | 5729/10924 | 1.01(0.94-1.08) | 0.880 | 26.1 |
East Asian | 7 | 1813/1766 | 1.19(0.91-1.56) | 0.209 | 82.6 | 9 | 1637/6948 | 0.83(0.68-1.02) | 0.074 | 73.3 | 6 | 2106/3099 | 1.29(1.18-1.42) | <0.001 | 0 |
West Asian | 3 | 565/531 | 2.07(1.33-3.22) | 0.001 | 59.5 | 2 | 237/424 | 0.75(0.41-1.36) | 0.337 | 81.4 | 0 | Â | Â | Â | Â |
African | 2 | 269/263 | 1.38(0.79-2.41) | 0.257 | 36.7 | 1 | 212/104 | 0.75(0.53-1.07) | 0.110 | / | 0 | Â | Â | Â | Â |
Study subjects | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Normal subjects | 17 | 5501/8723 | 1.20(1.03-1.41) | 0.018 | 78.7 | 17 | 6949/13367 | 0.92(0.84-1.01) | 0.082 | 63.3 | 12 | 5897/9627 | 1.09(1.00-1.19) | 0.042 | 46.6 |
Subjects with T2D | 6 | 834/1965 | 1.18(0.90-1.54) | 0.222 | 52.2 | 8 | 1261/4667 | 0.88(0.76-1.02) | 0.098 | 47.0 | 4 | 672/1615 | 0.87(0.75-1.01) | 0.07 | 0 |
Subjects with MetS | 0 | Â | Â | Â | Â | 0 | Â | Â | Â | Â | 2 | 1084/2085 | 1.29(1.15-1.46) | <0.001 | 0 |
Subjects with RD | 1 | 63/141 | 2.06(1.10-3.83) | 0.023 | / | 1 | 63/141 | 0.64(0.39-1.03) | 0.063 | / | 1 | 63/141 | 1.45(0.90-2.32) | 0.129 | / |
Subjects with RA | 0 | Â | Â | Â | Â | 1 | 119/555 | 0.79(0.57-1.09) | 0.151 | / | 1 | 119/555 | 1.01(0.73-1.40) | 0.941 | / |
Sample size | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
More than 1000 | 5 | 2911/6409 | 1.01(0.80-1.28) | 0.912 | 84.5 | 8 | 5006/13809 | 0.93(0.84-1.04) | 0.216 | 65.2 | 7 | 5274/9800 | 1.13(1.03-1.25) | 0.014 | 62.5 |
Less than 1000 | 19 | 3487/4420 | 1.30(1.12-1.52) | 0.001 | 63.9 | 19 | 3386/4921 | 0.87(0.78-0.97) | 0.015 | 56.0 | 13 | 2561/4223 | 1.04(0.93-1.18) | 0.488 | 49.6 |
Genotyping method | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
TaqMan | 9 | 3101/4986 | 1.13(0.94-1.37) | 0.188 | 70.8 | 10 | 3362/5571 | 0.93(0.85-1.01) | 0.098 | 31.6 | 9 | 3284/5572 | 1.00(0.91-1.10) | 0.959 | 33.8 |
PCR-RFLP | 11 | 2942/5167 | 1.25(1.01-1.56) | 0.043 | 80.6 | 9 | 1958/4516 | 0.80(0.68-0.94) | 0.006 | 63.1 | 5 | 1388/4057 | 1.19(1.03-1.39) | 0.023 | 43.2 |
Other | 4 | 355/676 | 1.44(0.99-2.11) | 0.058 | 54.3 | 8 | 3072/8643 | 0.97(0.83-1.14) | 0.728 | 64.7 | 6 | 3163/4394 | 1.15(0.98-1.35) | 0.090 | 64.0 |