TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis

Lu, Yingchang; Boer, Jolanda MA; Barsova, Roza M; Favorova, Olga; Goel, Anuj; Müller, Michael; Feskens, Edith JM

doi:10.1186/1471-2350-13-39

BMC Medical Genetics

Table 1 Characteristics of studies included in the meta-analysis ^a

From: TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis

Study	Country	Design	Cases				Controls					Outcome
Study	Country	Design	Genotypes					Genotypes			p_HWE^c	Outcome
rs1800468 (−800 G/A)			N	GG	AG	AA	N	GG	AG	AA
Crobu et al, 2008 [22]	Italy	CC	201	175	25	1	201	168	31	2	0.65	MI
Sie et al, 2006 [21]	Netherlands	CO	358	288	66	4	6098	5071	984	43	0.58	MI
Syrris et al,1998 [14]	England	CC	655	541	110	4	244	207	36	1	1	CAD
Cambien et al,1996 [16]	FR and NIE	CC	563	472	88	3	629	534	89	6	0.28	MI
rs1800469 (−509 C/T)				CC	CT	TT		CC	CT	TT
Sudomoina et al, 2010 [36]^b	Russia	CC	264	77	150	37	212	90	103	19	0.22	MI
Drenos et al, 2009 [37]	England	CC	240	120	100	20	2143	1090	885	168	0.56	CAD
Crobu et al, 2008 [22]	Italy	CC	201	67	87	47	201	80	92	29	0.76	MI
Koch et al, 2006 [20]	Germany	CC	3657	1581	1659	417	1211	564	508	139	0.13	MI
Sie et al, 2006 [21]	Netherlands	CO	355	171	156	28	6037	3043	2441	553	0.05	MI
Syrris et al, 1998 [14]	England	CC	655	301	284	70	244	124	97	23	0.54	CAD
Cambien et al, 1996 [16]	FR and NIE	CC	563	240	257	66	629	263	297	69	0.29	MI
rs1982073 (868 T/C)				TT	TC	CC		TT	TC	CC
Najar et al, 2011 [11]	Iran	CC	900	301	424	175	900	395	403	102	1	MI
Crobu et al, 2008 [22]	Italy	CC	201	55	88	58	201	69	101	31	0.66	MI
Koch et al, 2006 [20]	Germany	CC	3657	1235	1802	620	1211	458	565	188	0.55	MI
Sie et al, 2006 [21]	Netherlands	CO	343	135	164	44	5844	2322	2698	824	0.37	MI
Yokota et al, 2000 [23]	Japan	CC	315	89	185	41	591	149	295	147	1	MI
Syrris et al, 1998 [14]	England	CC	655	242	306	107	244	102	109	33	0.68	CAD
Cambien et al, 1996 [16]	FR and NIE	CC	563	181	277	105	629	225	297	107	0.62	MI
rs1800471 (913 G/C)				GG	GC	CC		GG	GC	CC
Drenos et al, 2009 [37]	England	CC	234	187	45	2	2071	1723	331	17	0.78	CAD
Koch et al, 2006 [20]	Germany	CC	3657	3149	486	22	1211	1063	141	7	0.33	MI
Sie et al, 2006 [21]	Netherlands	CO	343	297	45	1	5844	4992	823	29	0.51	MI
Syrris et al, 1998 [14]	England	CC	655	558	95	2	244	214	30	0	0.61	CAD
Cambien et al, 1996 [16]	FR and NIE	CC	563	464	92	7	629	546	81	2	1	MI
rs1800472 (11929 C/T)				CC	CT	TT		CC	CT	TT
Drenos et al, 2009 [37]	England	CC	241	234	7	0	2145	2052	89	4	0.02	CAD
Koch et al, 2006 [20]	Germany	CC	3657	3421	231	5	1211	1138	72	1	1	MI
Syrris et al, 1998 [14]	England	CC	655	622	33	0	244	237	7	0	1	CAD
Cambien et al, 1996 [16]	FR and NIE	CC	590	563	27	0	629	585	42	2	0.20	MI

FR and NIE, France and Northern Ireland; CC, case–control; CO, cohort; MI, myocardial infarction; CAD, coronary artery disease.
a, For rs1800468, rs1982073 and rs1800471, 10090 additional subjects were included for the co-dominant model analysis from the PROCARDIS study [25]; for rs1800469, additional 10090 and 80016 subjects were included for the co-dominant model analysis, respectively from the PROCARDIS study [25] and the CARDIoGRAM study [24] (Additional file 2).
b, Additional unpublished data have been included.
c, The p values for Hardy-Weinberg equilibrium were derived from Fisher’s exact test.

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