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Table 3 Association of the COX-2 variants with CIMT, Cdist and cholesterol values.

From: No Association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study

Phenotype

Variant

Minor/major

P

P

Q

Measured mean value

Number of individuals

 
  

allele

unadjusted

adjusted†

adjusted ††

hommajor

het

hom minor

hom major

het

hom minor

total

Mean carotid intima-media thickness (mm)

rs4648261

A/G

0.046

0.116

0.896

0.58

0.57

0.53

1583

99

4

1686

Max carotid intima-media thickness (mm)

rs4648261

A/G

0.048

0.121

0.477

0.62

0.61

0.56

1583

99

4

1686

Carotid distensibility (% /10 mmHg)

rs689470

T/C

0.005

0.031

0.137

2.17

2.42

 

2000

71

 

2071

 

rs689462

C/A

0.005

0.031

0.137

2.17

2.42

 

2000

71

 

2071

Total cholesterol (mmol/l)

rs5275

C/T

0.014

0.007

0.017

5.20

5.11

5.05

955

930

208

2093

LDL cholesterol (mmol/l)

rs5275

C/T

0.009

0.006

0.022

3.31

3.24

3.16

940

921

204

2065

  1. † linear regression model, adjusted with gender, age, BMI and smoking status.
  2. †† false discovery rate corrected p-values (= q-values) adjusted with gender, age, BMI and smoking status.
  3. hom major = major allele homozygote, het = heterozygote, hom minor = minor allele homozygote.
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BMC Medical Genetics

ISSN: 1471-2350

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