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Table 2 SNPs evaluated in the study

From: Polymorphisms in the mitochondrial oxidative phosphorylation chain genes as prognostic markers for colorectal cancer

Gene

Complex

SNP

Major/minor allele

Location

MAF

NDUFS2

I

rs33941127

C/T

Promoter

T - 0.21

NDUFS2

I

rs3813623

G/T

5′-UTR

T - 0.15

NDUFS2

I

rs11538340

C/A

Coding P20T

A - 0.06

NDUFS2

I

rs11576415

C/G

Coding P352A

G - 0.09

NDUFS2

I

rs1136224

A/G

3′-UTR

G - 0.17

UQCRB

III

rs7836698

C/T

3′-UTR

T - 0.42

UQCRB

III

rs10504961

C/T

3′-UTR

T - 0.50

COX5B

IV

rs11904110

T/C

Promoter

C – 0.06

COX6B1

IV

rs6510502

A/C

Promoter

C - 0.13

COX6B1

IV

rs10420252

G/A

5′-UTR

A - 0.10

ATP5C1

V

rs11255367

G/A

Promoter

A - 0.12

ATP5C1

V

rs2802460

T/C

Promoter

C - 0.26

ATP5C1

V

rs4655

T/C

3′-UTR

C - 0.36

GAPDH

 

rs7971637

C/T

Promoter

T - 0.19

GAPDH

 

rs1136666

C/G

5′-UTR

G - 0.26

HSPD1

 

rs1116734

C/G

Promoter

G - 0.33

  1. Two additional SNPs were genotyped, but showed only one allele in the 613 samples: rs2071038 (COX5B) and rs955 (HSPD1).
  2. MAF, minor allele frequency in the 613 CRC patients investigated; NDUFS2, NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase); UQCRB, ubiquinol-cytochrome c reductase binding protein; COX5B, cytochrome c oxidase subunit Vb; COX6B1, cytochrome c oxidase subunit VIb, polypeptide 1; ATP5C1, ATP synthase, H + transporting, mitochondrial F1 complex, gamma polypeptide 1; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HSPD1, heat shock 60kDa protein 1 (chaperonin).