Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)

Table 3 Association of HbA _1c with the 11 SNP genetic risk score by race-ethnicity, Third National Health and Nutrition Examination Survey (NHANES III)

Race/ethnicity	β (SE)¹	p-value²	Sample N	Genetic Risk Score (SE)⁴	R² Without Score³	R²With Score³	R² Difference	HbA_1c (%) difference top - bottom 10% of score distribution
Non-Hispanic White
HbA _1c (%)	0.012 (0.006)	0.04	1231	10.42 (0.07)	0.214	0.218	0.004	0.49
Non-Hispanic Black
HbA _1c (%)	0.007 (0.008)	0.39	901	10.95 (0.09)	0.095	0.096	0.001	0.56
Mexican Americans
HbA _1c (%)	0.021 (0.008)	0.005	909	10.67 (0.08)	0.131	0.168	0.037	0.54

HbA _1c: Hemoglobin A_1c (glycated hemoglobin); SE: standard error.
1. β-coefficients (SE) for the per-risk allele increase in HbA_1c (%) from linear regression models fro the risk score adjusted for age and sex.
2. p-values for β-coefficients based on Satterthwaite adjusted-F test.
3. Adjusted R² for regression models with and without (age and sex only) weighted genetic risk score.
4. p = <.0001 for the global difference in weighted genetic risk score across race-ethnic groups.

ISSN: 1471-2350