Genotyping of a tri-allelic polymorphism by a novel melting curve assay in MTHFD1L: an association study of nonsyndromic Cleft in Ireland

Table 2 TDT analysis for DIP rs3832406 and SNP rs17080476 in all cleft sample

		Allele	Passed		Not Passed		GRR¹ (95% CI)	P-value
DIP rs3832406			n	%	n	%
	Isolated CLP	1	194	55.6	155	44.4	1.3 (1.0, 1.5)	0.0372
		2	119	47.2	133	52.8	0.9 (0.7, 1.1)	0.3781
		3	88	43.8	113	56.2	0.8 (0.6, 1.0)	0.0786
		Total	401		401
	Multiple CLP	1	216	56.5	166	43.5	1.3 (1.1, 1.6)	0.0107
		2	128	46.5	147	53.5	0.9 (0.7, 1.1)	0.2523
		3	92	42.8	123	57.2	0.7 (0.6,1.0)	0.0351
		Total	436		436
	Isolated CPO	1	145	52.5	131	47.5	1.1 (0.9, 1.4)	0.3996
		2	86	47.8	94	52.2	0.9 (0.7, 1.2)	0.5511
		3	77	48.1	83	51.9	0.9 (0.7, 1.3)	0.6353
		Total	308		308
	Multiple CPO	1	188	52.2	172	47.8	1.1 (0.9, 1.3)	0.3992
		2	115	48.9	120	51.1	1.0 (0.7, 1.2)	0.7443
		3	101	47.4	112	52.6	0.9 (0.7, 1.2)	0.4512
		Total	404		404
SNP rs17080476	Isolated CLP	G	132	54.3	111	45.7	1.2 (0.9, 1.5)	0.1785
	Isolated CLP	A	111	45.7	132	54.3
		Total	243		243
	Multiple CLP	G	144	54.3	121	45.7	1.2 (0.9, 1.5)	0.1582
	Multiple CLP	A	121	45.7	144	54.3
		Total	265		265
	Isolated CPO	G	87	50.6	85	49.4	1.0 (0.8, 1.4)	0.8788
	Isolated CPO	A	85	49.4	87	50.6
		Total	172		172
	Multiple CPO	G	119	50.9	115	49.1	1.0 (0.8, 1.3)	0.7937
	Multiple CPO	A	115	49.1	119	50.9
		Total	234		234

ISSN: 1471-2350