From: Systems analysis of inflammatory bowel disease based on comprehensive gene information
Criteria for selection | No. of IBDmild genes | No. of IBDsevere genes |
---|---|---|
(1) Collect IBD-associated genes from databases for human diseases. | 1,264 | 869 |
(2) Rank the genes by the frequency of the IBD-association in the databases (equation (5)). Cut off the genes falling short of the lowest frequency of a gene validated its disease association by literatures (TNF for IBDmild and CRP for IBDsevere). | 250 | 253 |
(3) Select the genes interconnected by PPI evidence. | 146 | 151 |
(4) Rank the genes by GO based similarity score (SSM, equation (4)) to IBD drug targets. Cut off the genes under the upper quartile of the random distribution of SSM scores against IBD drug targets. | 46 | 62 |