From: Systems analysis of inflammatory bowel disease based on comprehensive gene information
HDN | Functional category | Gene |
---|---|---|
IBDmild | immunoregulation | ICAM1, IL2, IL23A, IL23R, IL4, CRP, IL11, IL2RA, IL4R, IRAK3, TYK2 |
 | innate immunity | CD14, TLR2, TLR4, TLR1, TLR6, IFNG, IL8 |
 | inflammation and immunoregulation | CCL2, IL12B, IL17, IL1A, IL1RN, NFKB1, NFKBIA, CCL11, CCL26, IL10RA, IL18RAP |
 | inflammation and apoptosis | IL1B, IRF5, TNFSF1A, IL15, JAK2, STAT6 |
 | cell growth, apoptosis and tumorigenesis | TP53, PTPN11, STAT3, TGFB1 |
 | atherosclerosis and tissue remodeling | SERPINE1, TIMP1, A2M |
 | diabetes related | PPARG |
 | prostaglandin biosynthesis | PTGS1, PTGS2 |
IBDsevere | immunoregulation | ICAM1, IL2, IL23A, IL23R, IL4, B2M, CD28, CX3CL1, CTLA4, HLA-C, KLRC1, IL12A, IL12RB2, STAT2, STAT4 |
 | innate immunity | CD14, TLR2, TLR4, IFNG, IL8 |
 | inflammation and immunoregulation | CCL2, IL12B, IL17, IL1A, IL1RN, NFKB1, NFKBIA, CCL5, CSF2, IL1R1, IL6, IL6R, IL18, NR3C1 |
 | inflammation and apoptosis | IL1B, IRF5, TNFSF1A, IL15 |
 | apoptosis | FASLG, TNFAIP3, TNFRSF1B, TRADD |
 | cell growth and tumorigenesis | TP53, IGF1, IGFBP3, TGFB1, TGFBR1, SOCS1 |
 | aging and tumorigenesis | SOD1, SOD2 |
 | atherosclerosis and tissue remodeling | SERPINE1, TIMP1, EDN1, MMP3, PLAT, SELE |
 | diabetes related | PPARG, LEP, PPARA |