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Table 2 Functional classification of genes consist of HDNs for IBD

From: Systems analysis of inflammatory bowel disease based on comprehensive gene information

HDN

Functional category

Gene

IBDmild

immunoregulation

ICAM1, IL2, IL23A, IL23R, IL4, CRP, IL11,

IL2RA, IL4R, IRAK3, TYK2

 

innate immunity

CD14, TLR2, TLR4, TLR1, TLR6, IFNG, IL8

 

inflammation and immunoregulation

CCL2, IL12B, IL17, IL1A, IL1RN, NFKB1,

NFKBIA, CCL11, CCL26, IL10RA, IL18RAP

 

inflammation and apoptosis

IL1B, IRF5, TNFSF1A, IL15, JAK2, STAT6

 

cell growth, apoptosis and tumorigenesis

TP53, PTPN11, STAT3, TGFB1

 

atherosclerosis and tissue remodeling

SERPINE1, TIMP1, A2M

 

diabetes related

PPARG

 

prostaglandin biosynthesis

PTGS1, PTGS2

IBDsevere

immunoregulation

ICAM1, IL2, IL23A, IL23R, IL4, B2M, CD28, CX3CL1, CTLA4, HLA-C, KLRC1, IL12A,

IL12RB2, STAT2, STAT4

 

innate immunity

CD14, TLR2, TLR4, IFNG, IL8

 

inflammation and immunoregulation

CCL2, IL12B, IL17, IL1A, IL1RN, NFKB1,

NFKBIA, CCL5, CSF2, IL1R1, IL6, IL6R, IL18, NR3C1

 

inflammation and apoptosis

IL1B, IRF5, TNFSF1A, IL15

 

apoptosis

FASLG, TNFAIP3, TNFRSF1B, TRADD

 

cell growth and tumorigenesis

TP53, IGF1, IGFBP3, TGFB1, TGFBR1, SOCS1

 

aging and tumorigenesis

SOD1, SOD2

 

atherosclerosis and tissue remodeling

SERPINE1, TIMP1, EDN1, MMP3, PLAT, SELE

 

diabetes related

PPARG, LEP, PPARA

  1. We annotated the genes by their functions according to EntrezGene database.