Comparison of I
-WT and I
-G60D channel deactivation. KCNE1-WT (A) and KCNE1-G60D (B) channel subunits co-expressed with KV7.1 in X.laevis oocytes in a 1:1 molar ratio. Current step protocol is shown as inset. (C) Enlargement of the tail-currents normalized to maximum current amplitude (gray: IKs-WT; black: IKs-G60D). Deactivation time constants (tau) were obtained by fitting the tail-current traces to a mono-exponential function (D).