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Figure 2 | BMC Medical Genetics

Figure 2

From: Functional effects of the TMEM43 Ser358Leu mutation in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy

Figure 2

Solubility assays. Solubility patterns for (A) desmosomal and (B) nuclear envelope proteins were assessed by immunoblots for soluble and insoluble protein fractions extracted from COS-7 cells transfected with wildtype (WT) TMEM43, mutant (Mut) TMEM43, or a 1:2 ratio of wildtype to mutant (WT + Mut) TMEM43. Sol, soluble fraction containing cytoplasmic (Cyt) proteins; Insol, insoluble fraction containing membrane bound proteins. No differences in solubility patterns were found, suggesting that the presence of mutant TMEM43 did not alter the stability of TMEM43 or of other desmosomal or nuclear envelope proteins.

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BMC Medical Genetics

ISSN: 1471-2350

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