Skip to main content

Table 2 Association of significant EMID2 variants with nasal polyps in the overall asthmatic patients (n = 467)

From: Possible role of EMID2 on nasal polyps pathogenesis in Korean asthma patients

SNP/Haplotype MAF Co-dominant   Dominant    Recessive Statistical Power
  Polyp-positive
(n = 158)
Polyp-negative (n = 309) OR(95%CI) P* P corr ** OR(95%CI) P* P corr ** OR(95%CI) P* P corr **  
rs6945102C > T 0.228 0.322 0.62(0.45-0.87) 0.005 NS 0.60(0.40-0.91) 0.02 NS 0.39(0.16-0.92) 0.03 NS 62.03
rs4729697A > G 0.224 0.321 0.61(0.44-0.86) 0.004 NS 0.59(0.39-0.89) 0.01 NS 0.39(0.16-0.93) 0.03 NS 60.92
rs221G > A 0.252 0.337 0.67(0.49-0.93) 0.02 NS 0.64(0.43-0.97) 0.04 NS 0.48(0.22-1.06) 0.07 - 66.93
rs10435333G > A 0.252 0.337 0.67(0.48-0.93) 0.02 NS 0.64(0.43-0.97) 0.03 NS 0.49(0.22-1.07) 0.07 - 66.93
rs6947185C > A 0.433 0.537 0.69(0.52-0.92) 0.01 NS 0.69(0.44-1.09) 0.11 - 0.53(0.32-0.87) 0.01 NS 72.99
rs4727494G > A 0.263 0.359 0.65(0.47-0.90) 0.009 NS 0.65(0.43-0.98) 0.04 NS 0.40(0.18-0.87) 0.02 NS 66.22
rs13233066G > A 0.275 0.362 0.70(0.51-0.95) 0.02 NS 0.65(0.43-0.97) 0.04 NS 0.60(0.30-1.19) 0.14 - 69.05
rs1008064T > C 0.494 0.430 1.32(1.00-1.75) 0.05 NS 1.46(0.94-2.26) 0.10 - 1.48(0.92-2.38) 0.10 - 77.44
rs1543883T > C 0.506 0.450 1.32(1.00-1.76) 0.05 NS 1.51(0.96-2.38) 0.08 - 1.41(0.88-2.25) 0.16 - 78.55
rs13245946C > T 0.108 0.073 1.53(0.95-2.45) 0.08 - 1.36(0.79-2.33) 0.26 - 13.01(1.45-116.41) 0.02 NS 41.62
EMID2_BL1_ht2 0.180 0.290 0.54(0.37-0.77) 0.0008 0.03 0.53(0.35-0.82) 0.004 NS 0.22(0.06-0.74) 0.01 NS 71.84
EMID2_BL2_ht2 0.259 0.356 0.64(0.47-0.89) 0.007 NS 0.63(0.42-0.95) 0.03 NS 0.42(0.19-0.92) 0.03 NS 81.64
EMID2_BL3_ht1 0.453 0.510 0.74(0.56-0.98) 0.03 NS 0.66(0.42-1.02) 0.06 - 0.67(0.42-1.08) 0.10 - 88.51
  1. *P-values at 0.05 level of significance adjusted for initial diagnosed age, sex, smoking status, atopy and AERD. Significant values are shown in bold.
  2. **P-values after multiple testing corrections (Meff = 42.7377).
  3. MAF, minor allele frequency; OR, odds ratio; CI, confidence interval; NS, not significant.