Possible role of EMID2 on nasal polyps pathogenesis in Korean asthma patients

Pasaje, Charisse Flerida Arnejo; Bae, Joon Seol; Park, Byung-Lae; Cheong, Hyun Sub; Kim, Jeong-Hyun; Jang, An-Soo; Uh, Soo-Taek; Park, Choon-Sik; Shin, Hyoung Doo

doi:10.1186/1471-2350-13-2

BMC Medical Genetics

Table 2 Association of significant EMID2 variants with nasal polyps in the overall asthmatic patients (n = 467)

From: Possible role of EMID2 on nasal polyps pathogenesis in Korean asthma patients

SNP/Haplotype	MAF		Co-dominant			Dominant			Recessive			Statistical Power
	Polyp-positive (n = 158)	Polyp-negative (n = 309)	OR(95%CI)	P*	P ^corr **	OR(95%CI)	P*	P ^corr **	OR(95%CI)	P*	P ^corr **
rs6945102C > T	0.228	0.322	0.62(0.45-0.87)	0.005	NS	0.60(0.40-0.91)	0.02	NS	0.39(0.16-0.92)	0.03	NS	62.03
rs4729697A > G	0.224	0.321	0.61(0.44-0.86)	0.004	NS	0.59(0.39-0.89)	0.01	NS	0.39(0.16-0.93)	0.03	NS	60.92
rs221G > A	0.252	0.337	0.67(0.49-0.93)	0.02	NS	0.64(0.43-0.97)	0.04	NS	0.48(0.22-1.06)	0.07	-	66.93
rs10435333G > A	0.252	0.337	0.67(0.48-0.93)	0.02	NS	0.64(0.43-0.97)	0.03	NS	0.49(0.22-1.07)	0.07	-	66.93
rs6947185C > A	0.433	0.537	0.69(0.52-0.92)	0.01	NS	0.69(0.44-1.09)	0.11	-	0.53(0.32-0.87)	0.01	NS	72.99
rs4727494G > A	0.263	0.359	0.65(0.47-0.90)	0.009	NS	0.65(0.43-0.98)	0.04	NS	0.40(0.18-0.87)	0.02	NS	66.22
rs13233066G > A	0.275	0.362	0.70(0.51-0.95)	0.02	NS	0.65(0.43-0.97)	0.04	NS	0.60(0.30-1.19)	0.14	-	69.05
rs1008064T > C	0.494	0.430	1.32(1.00-1.75)	0.05	NS	1.46(0.94-2.26)	0.10	-	1.48(0.92-2.38)	0.10	-	77.44
rs1543883T > C	0.506	0.450	1.32(1.00-1.76)	0.05	NS	1.51(0.96-2.38)	0.08	-	1.41(0.88-2.25)	0.16	-	78.55
rs13245946C > T	0.108	0.073	1.53(0.95-2.45)	0.08	-	1.36(0.79-2.33)	0.26	-	13.01(1.45-116.41)	0.02	NS	41.62
EMID2_BL1_ht2	0.180	0.290	0.54(0.37-0.77)	0.0008	0.03	0.53(0.35-0.82)	0.004	NS	0.22(0.06-0.74)	0.01	NS	71.84
EMID2_BL2_ht2	0.259	0.356	0.64(0.47-0.89)	0.007	NS	0.63(0.42-0.95)	0.03	NS	0.42(0.19-0.92)	0.03	NS	81.64
EMID2_BL3_ht1	0.453	0.510	0.74(0.56-0.98)	0.03	NS	0.66(0.42-1.02)	0.06	-	0.67(0.42-1.08)	0.10	-	88.51

*P-values at 0.05 level of significance adjusted for initial diagnosed age, sex, smoking status, atopy and AERD. Significant values are shown in bold.
**P-values after multiple testing corrections (Meff = 42.7377).
MAF, minor allele frequency; OR, odds ratio; CI, confidence interval; NS, not significant.

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