Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study

Table 2 Case-control comparison of SNP genotypes

	Total n	Total n	n-controls			n-cases						p		q
SNP rs marker (gene name)	Controls (freq)^a	Cases (freq)^a	0	1	2	0	1	2	OR	CI	trend	recess.	dom.	Holm
rs1135840	395	500	133	183	79	145	240	115	1.14	0.94-1.37	0.174	0.367	0.188	1
(CYP2D6)	0.44	0.56	0.34	0.56	0.2	0.39	0.5	0.23
rs3738136	412	521	375	36	1	469	48	4	1.11	0.73-1.7	0.625	0.338	0.78	1
(PINK-1)	0.44	0.56	0.91	0.19	0	0.9	0.19	0.01
rs1043424	414	520	217	165	32	281	208	31	0.89	0.72-1.1	0.27	0.19	0.478	1
(PINK-1)	0.44	0.56	0.52	0.4	0.18	0.54	0.4	0.16
rs2234694	412	521	372	38	2	478	41	2	0.84	0.54-1.28	0.411	0.813	0.408	1
(SOD1)	0.44	0.56	0.9	0.19	0	0.92	0.18	0
rs4880	413	523	107	206	100	116	264	143	1.14	0.95-1.38	0.157	0.22	0.279	1
(SOD2)	0.44	0.56	0.36	0.5	0.24	0.22	0.5	0.37
rs662	414	521	211	160	43	256	217	48	1.03	0.85-1.26	0.757	0.65	0.497	1
(PON1)	0.44	0.56	0.51	0.49	0.1	0.59	0.42	0.09
rs854560	412	521	181	176	55	213	242	66	1.02	0.84-1.23	0.875	0.661	0.606	1
(PON1)	0.44	0.56	0.44	0.43	0.13	0.41	0.56	0.13
rs705381	409	523	231	148	30	293	201	29	0.98	0.79-1.21	0.845	0.355	0.831	1
(PON1)	0.44	0.56	0.6	0.46	0.11	0.66	0.48	0.16
rs7493	413	523	237	148	28	315	181	27	0.9	0.73-1.12	0.349	0.265	0.535	1
(PON2)	0.44	0.56	0.67	0.46	0.17	0.6	0.45	0.15
rs12026	412	521	237	147	28	314	180	27	0.9	0.73-1.12	0.364	0.267	0.558	1
(PON2)	0.44	0.56	0.68	0.46	0.17	0.6	0.45	0.15
rs1052553	406	324	231	148	27	281	40	3	0.23	0.16-0.32	< 0.001	0.001	< 0.001	< 0.001
(MAPT)	0.56	0.44	0.67	0.46	0.17	0.97	0.12	0.01

Logistic regression trend test comparing genotype differences between cases and controls, adjusted for age (age at death for cases, age at draw for controls). ^aFrequency = number of samples in a particular variable category (i.e. "cases" or "0, 1, 2") divided by the total n for that variable (i.e. "cases + controls" or "0+1+2"). "0" represents common allele homozygous genotype for SNP tested, 1 = heterozygote, 2 = minor allele homozygous. OR = odds ratios for increase in the number of alleles (i.e. from 0 to 1 or 1 to 2); CI = 95% confidence intervals for ORs; p = p-values reported for trend test as well as for recessive (recess.) and dominant (dom.) models;q = q-values for multiple testing adjustment using Holm's method.

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