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Table 2 Case-control comparison of SNP genotypes

From: Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study

  Total
n
Total
n
n-controls n-cases    p   q
SNP rs marker (gene name) Controls (freq)a Cases (freq)a 0 1 2 0 1 2 OR CI trend recess. dom. Holm
rs1135840 395 500 133 183 79 145 240 115 1.14 0.94-1.37 0.174 0.367 0.188 1
(CYP2D6) 0.44 0.56 0.34 0.56 0.2 0.39 0.5 0.23       
rs3738136 412 521 375 36 1 469 48 4 1.11 0.73-1.7 0.625 0.338 0.78 1
(PINK-1) 0.44 0.56 0.91 0.19 0 0.9 0.19 0.01       
rs1043424 414 520 217 165 32 281 208 31 0.89 0.72-1.1 0.27 0.19 0.478 1
(PINK-1) 0.44 0.56 0.52 0.4 0.18 0.54 0.4 0.16       
rs2234694 412 521 372 38 2 478 41 2 0.84 0.54-1.28 0.411 0.813 0.408 1
(SOD1) 0.44 0.56 0.9 0.19 0 0.92 0.18 0       
rs4880 413 523 107 206 100 116 264 143 1.14 0.95-1.38 0.157 0.22 0.279 1
(SOD2) 0.44 0.56 0.36 0.5 0.24 0.22 0.5 0.37       
rs662 414 521 211 160 43 256 217 48 1.03 0.85-1.26 0.757 0.65 0.497 1
(PON1) 0.44 0.56 0.51 0.49 0.1 0.59 0.42 0.09       
rs854560 412 521 181 176 55 213 242 66 1.02 0.84-1.23 0.875 0.661 0.606 1
(PON1) 0.44 0.56 0.44 0.43 0.13 0.41 0.56 0.13       
rs705381 409 523 231 148 30 293 201 29 0.98 0.79-1.21 0.845 0.355 0.831 1
(PON1) 0.44 0.56 0.6 0.46 0.11 0.66 0.48 0.16       
rs7493 413 523 237 148 28 315 181 27 0.9 0.73-1.12 0.349 0.265 0.535 1
(PON2) 0.44 0.56 0.67 0.46 0.17 0.6 0.45 0.15       
rs12026 412 521 237 147 28 314 180 27 0.9 0.73-1.12 0.364 0.267 0.558 1
(PON2) 0.44 0.56 0.68 0.46 0.17 0.6 0.45 0.15       
rs1052553 406 324 231 148 27 281 40 3 0.23 0.16-0.32 < 0.001 0.001 < 0.001 < 0.001
(MAPT) 0.56 0.44 0.67 0.46 0.17 0.97 0.12 0.01       
  1. Logistic regression trend test comparing genotype differences between cases and controls, adjusted for age (age at death for cases, age at draw for controls). aFrequency = number of samples in a particular variable category (i.e. "cases" or "0, 1, 2") divided by the total n for that variable (i.e. "cases + controls" or "0+1+2"). "0" represents common allele homozygous genotype for SNP tested, 1 = heterozygote, 2 = minor allele homozygous. OR = odds ratios for increase in the number of alleles (i.e. from 0 to 1 or 1 to 2); CI = 95% confidence intervals for ORs; p = p-values reported for trend test as well as for recessive (recess.) and dominant (dom.) models;q = q-values for multiple testing adjustment using Holm's method.