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Table 3 Departure from multiplicativity between CD-associated NOD2 alleles and smoking status at diagnosis among patients with Crohn's disease

From: A case-only study of gene-environment interaction between genetic susceptibility variants in NOD2 and cigarette smoking in Crohn's disease aetiology

 

Smoking status at diagnosis

Unadjusted

Adjusted*

 

Smoker at diagnosis

Non-smoker at diagnosis

OR

95% CI

p-value

OR

95% CI

p-value

Combined Allele Analysis

        

   Wild type at all 3 loci

311 (59.6%)

384 (50.5%)

1.00

-

-

1.00

-

-

   Carrier of ≥ 1 risk allele

211 (40.4%)

377 (49.5%)

0.69

0.55-0.87

0.001

0.68

0.51-0.89

0.005

R702W Polymorphism

        

   Wild type

429 (82.2%)

608 (79.9%)

1.00

-

-

1.00

-

-

   Carrier of risk allele

93 (17.8%)

153 (20.1%)

0.86

0.65-1.14

0.30

0.82

0.57-1.16

0.27

G908R Polymorphism

        

   Wild type

475 (91.0%)

689 (90.5%)

1.00

-

-

1.00

-

-

   Carrier of risk allele

47 (9.0%)

72 (9.5%)

0.94

0.64-1.39

0.78

0.93

0.57-1.49

0.76

1007fs Polymorphism

        

   Wild type

420 (80.5%)

524 (68.9%)

1.00

-

-

1.00

-

-

   Carrier of risk allele

102 (19.5%)

237 (31.1%)

0.54

0.41-0.70

3 × 10-6

0.53

0.39-0.73

7 × 10 -5

  1. * adjusted for sex, age at diagnosis, age at study inclusion, family history, and year of recruitment
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BMC Medical Genetics

ISSN: 1471-2350

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