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Table 3 Departure from multiplicativity between CD-associated NOD2 alleles and smoking status at diagnosis among patients with Crohn's disease

From: A case-only study of gene-environment interaction between genetic susceptibility variants in NOD2 and cigarette smoking in Crohn's disease aetiology

  Smoking status at diagnosis Unadjusted Adjusted*
  Smoker at diagnosis Non-smoker at diagnosis OR 95% CI p-value OR 95% CI p-value
Combined Allele Analysis         
   Wild type at all 3 loci 311 (59.6%) 384 (50.5%) 1.00 - - 1.00 - -
   Carrier of ≥ 1 risk allele 211 (40.4%) 377 (49.5%) 0.69 0.55-0.87 0.001 0.68 0.51-0.89 0.005
R702W Polymorphism         
   Wild type 429 (82.2%) 608 (79.9%) 1.00 - - 1.00 - -
   Carrier of risk allele 93 (17.8%) 153 (20.1%) 0.86 0.65-1.14 0.30 0.82 0.57-1.16 0.27
G908R Polymorphism         
   Wild type 475 (91.0%) 689 (90.5%) 1.00 - - 1.00 - -
   Carrier of risk allele 47 (9.0%) 72 (9.5%) 0.94 0.64-1.39 0.78 0.93 0.57-1.49 0.76
1007fs Polymorphism         
   Wild type 420 (80.5%) 524 (68.9%) 1.00 - - 1.00 - -
   Carrier of risk allele 102 (19.5%) 237 (31.1%) 0.54 0.41-0.70 3 × 10-6 0.53 0.39-0.73 7 × 10 -5
  1. * adjusted for sex, age at diagnosis, age at study inclusion, family history, and year of recruitment