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Table 2 Departure from multiplicativity between CD-associated NOD2 alleles and ever smoking status among patients with Crohn's disease

From: A case-only study of gene-environment interaction between genetic susceptibility variants in NOD2 and cigarette smoking in Crohn's disease aetiology

 

Smoking status

Unadjusted

Adjusted*

 

Ever smoked

Never smoked

OR

95% CI

p-value

OR

95% CI

p-value

Combined Allele Analysis

        

   Wild type at all 3 loci

549 (58.1%)

336 (48.6%)

1.00

-

-

1.00

-

-

   Carrier of ≥ 1 risk allele

396 (41.9%)

355 (51.4%)

0.68

0.56-0.83

1 × 10-4

0.71

0.56-0.90

0.005

R702W Polymorphism

        

   Wild type

776 (82.1%)

540 (78.1%)

1.00

-

-

1.00

-

-

   Carrier of risk allele

169 (17.9%)

151 (21.9%)

0.78

0.61-1.00

0.04

0.80

0.59-1.07

0.14

G908R Polymorphism

        

   Wild type

858 (90.8%)

626 (90.6%)

1.00

-

-

1.00

-

-

   Hetero- or homozygote

87 (9.2%)

65 (9.4%)

0.98

0.70-1.37

0.89

1.00

0.67-1.53

0.96

1007fs Polymorphism

        

   Wild type

735 (77.8%)

477 (69.0%)

1.00

-

-

1.00

-

-

   Carrier of risk allele

210 (22.2%)

214 (31.0%)

0.64

0.51-0.80

7 × 10-5

0.64

0.49-0.83

9 × 10 -4

  1. * adjusted for sex, age at diagnosis, age at study inclusion, family history, and year of recruitment
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BMC Medical Genetics

ISSN: 1471-2350

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