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Table 2 Departure from multiplicativity between CD-associated NOD2 alleles and ever smoking status among patients with Crohn's disease

From: A case-only study of gene-environment interaction between genetic susceptibility variants in NOD2 and cigarette smoking in Crohn's disease aetiology

  Smoking status Unadjusted Adjusted*
  Ever smoked Never smoked OR 95% CI p-value OR 95% CI p-value
Combined Allele Analysis         
   Wild type at all 3 loci 549 (58.1%) 336 (48.6%) 1.00 - - 1.00 - -
   Carrier of ≥ 1 risk allele 396 (41.9%) 355 (51.4%) 0.68 0.56-0.83 1 × 10-4 0.71 0.56-0.90 0.005
R702W Polymorphism         
   Wild type 776 (82.1%) 540 (78.1%) 1.00 - - 1.00 - -
   Carrier of risk allele 169 (17.9%) 151 (21.9%) 0.78 0.61-1.00 0.04 0.80 0.59-1.07 0.14
G908R Polymorphism         
   Wild type 858 (90.8%) 626 (90.6%) 1.00 - - 1.00 - -
   Hetero- or homozygote 87 (9.2%) 65 (9.4%) 0.98 0.70-1.37 0.89 1.00 0.67-1.53 0.96
1007fs Polymorphism         
   Wild type 735 (77.8%) 477 (69.0%) 1.00 - - 1.00 - -
   Carrier of risk allele 210 (22.2%) 214 (31.0%) 0.64 0.51-0.80 7 × 10-5 0.64 0.49-0.83 9 × 10 -4
  1. * adjusted for sex, age at diagnosis, age at study inclusion, family history, and year of recruitment