| Ever Smokers | Never Smokers |  | Smokers at Diagnosis | Non-Smokers at Diagnosis |  | Total Sample | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Characteristic | n | % | n | % | p-value | n | % | n | % | p-value | n | % |
Total Participants n = 1636 | 945 | 57.8% | 691 | 42.2% | Â | 522 | 40.7% | 761 | 59.3% | Â | 1636 | 100.0% |
Sex | Â | Â | Â | Â | 0.09 | Â | Â | Â | Â | 0.02 | Â | Â |
   Men | 281 | 29.7% | 233 | 33.7% |  | 144 | 27.6% | 258 | 33.9% |  | 514 | 31.4% |
   Women | 664 | 70.3% | 458 | 66.3% |  | 378 | 72.4% | 503 | 66.1% |  | 1122 | 68.6% |
Age at Inclusion--Mean (Standard Deviation) | 40.8 | ± 10.9 | 36.3 | ± 12.9 | 2 × 10 -13 | 41.1 | ± 10.6 | 38.8 | ± 13.5 | 6 × 10 -4 | 38.9 | ± 12.0 |
Age at Diagnosis--Mean (Standard Deviation) | 27.4 | ± 10.1 | 24.1 | ± 10.1 | 7 × 10 -11 | 27.3 | ± 9.5 | 26.0 | ± 11.4 | 0.03 | 26 | ± 10.3 |
Family History | Â | Â | Â | Â | 0.17 | Â | Â | Â | Â | 0.43 | Â | Â |
   Yes | 229 | 24.2% | 196 | 28.4% |  | 75 | 14.4% | 128 | 16.8% |  | 425 | 26.0% |
   No | 463 | 49.0% | 320 | 46.3% |  | 295 | 56.5% | 408 | 53.6% |  | 783 | 47.9% |
   Unknown | 253 | 26.8% | 175 | 25.3% |  | 152 | 29.1% | 225 | 29.6% |  | 428 | 26.2% |
Combined Allele Analysis |  |  |  |  | 1 × 10 -4 |  |  |  |  | 0.001 |  |  |
   Wild Type | 549 | 58.1% | 336 | 48.6% |  | 311 | 59.6% | 384 | 50.5% |  | 885 | 54.1% |
   Carrier of ≥ 1 risk allele | 396 | 41.9% | 355 | 51.4% |  | 211 | 40.4% | 377 | 49.5% |  | 751 | 45.9% |
R702W Polymorphism | Â | Â | Â | Â | 0.12 | Â | Â | Â | Â | 0.34 | Â | Â |
   Wild Type (C/C) | 776 | 82.1% | 540 | 78.1% |  | 429 | 82.2% | 608 | 79.9% |  | 1316 | 80.4% |
   Heterozygote for risk allele (C/T) | 153 | 16.2% | 134 | 19.4% |  | 85 | 16.3% | 133 | 17.5% |  | 287 | 17.5% |
   Homozygote for risk allele (T/T) | 16 | 1.7% | 17 | 2.5% |  | 8 | 1.5% | 20 | 2.6% |  | 33 | 2.0% |
G908R Polymorphism | Â | Â | Â | Â | 0.93 | Â | Â | Â | Â | 0.12 | Â | Â |
   Wild Type (G/G) | 858 | 90.8% | 626 | 90.6% |  | 475 | 91.0% | 689 | 90.5% |  | 1484 | 90.7% |
   Heterozygote for risk allele (G/C) | 84 | 8.9% | 62 | 9.0% |  | 47 | 9.0% | 66 | 8.7% |  | 146 | 8.9% |
   Homozygote for risk allele (C/C) | 3 | 0.3% | 3 | 0.4% |  | 0 | 0.0% | 6 | 0.8% |  | 6 | 0.4% |
1007fs Polymorphism |  |  |  |  | 1 × 10 -4 |  |  |  |  | 7 × 10 -6 |  |  |
   Wild Type (-/-) | 735 | 77.8% | 477 | 69.0% |  | 420 | 80.5% | 524 | 68.9% |  | 1212 | 74.1% |
   Heterozygote for risk allele (-/C) | 174 | 18.4% | 166 | 24.0% |  | 88 | 16.9% | 187 | 24.6% |  | 340 | 20.8% |
   Homozygote for risk allele (C/C) | 36 | 3.8% | 48 | 6.9% |  | 14 | 2.7% | 50 | 6.6% |  | 84 | 5.1% |