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Figure 2 | BMC Medical Genetics

Figure 2

From: The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro

Figure 2

Partial bisulphite sequence of the FMR1 promoter region of a WT (upper panel), untreated FXS (E3 line, middle panel) and treated FXS cell line (E3 + 1 mM AFQ056 for 8 days; lower panel), from CpG site 7 to 15. After bisulphite treatment, the cytosines of the CpG sites were transformed into thymines in the WT cell line, while in the untreated and treated FXS cells they remained unmodified, demonstrating that AFQ056 treatment does not affect the DNA methylation status in the FMR1 promoter region.

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BMC Medical Genetics

ISSN: 1471-2350

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