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Table 2 Association between SNPs and lung cancer

From: Prediction of lung cancer risk in a Chinese population using a multifactorial genetic model

SNP

P HWE

Frequency of high-risk allele

Observed OR, (95% CI)*

P

Genetic variance explained†

Rs2736100

0.49

0.41

1.18 (1.09-1.27)

< 0.001

1.33%

Rs402710

0.43

0.68

1.10 (1.01-1.19)

0.034

0.40%

Rs1051730

0.05

0.02

1.09 (0.85-1.40)

0.108

-

Rs4083914

0.25

0.14

1.15 (1.03-1.28)

0.013

0.47%

Rs4488809

0.50

0.47

1.21 (1.11-1.30)

< 0.001

1.82%

  1. NOTE: CI, confidence interval; OR, odds ratio.
  2. *Odds ratio per copy of the high-risk allele.
  3. †The percentage of genetic variance was estimated under a liability threshold model: [2p (1-p)] β2 (p, risk allele frequency; β, additive allelic effect).