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Table 1 Demographic, clinical, and genetic characteristics of NAFLD cases stratified by the ultrasonography-determined steatosis degree †

From: Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese population

Variable

Steatosis grade

P-value‡

 

Mild

Moderate

Severe

 

Sample size

105

83

15

 

Age (years)

47.6 ± 13.3

47.4 ± 13.2

38.9 ± 13.9

0.06

BMI (kg/m2)

26.1 ± 3.7

27.2 ± 4.4

30.5 ± 5.3

< 0.01

ALT (IU/L)

30.9 ± 21.3

50.1 ± 36.1

106.3 ± 78.5

< 0.01

AST (IU/L)

28.8 ± 26.9

29.5 ± 13.4

59.8 ± 62.46

< 0.01

GGT (IU/L)

63.0 ± 83.8

55.8 ± 48.6

78.2 ± 47.7

> 0.10

Triglycerides (mmol/L)

1.8 ± 1.3

2.3 ± 1.5

2.4 ± 1.8

0.03

LDL-C (mmol/L)

3.4 ± 1.0

3.3 ± 1.1

3.1 ± 1.2

> 0.10

HDL-C (mmol/L)

1.3 ± 0.4

1.4 ± 0.8

1.1 ± 0.2

> 0.10

FBG (mmol/L )

6.0 ± 1.3

6.0 ± 1.1

6.7 ± 1.9

> 0.10

PNPLA3-I148M

    

II

52

18

0

7.6×10-8

IM

39

41

4

 

MM

14

24

11

 
  1. †Data are described by mean ± standard deviation for continuous variables.
  2. ‡For demographic and clinical variables nominal P-values were calculated by an F-test using ANOVA; for I148M the P-value was calculated by Fisher’s exact test. P-values for BMI, ALT, and AST remained < 0.01 after Bonferroni multiple testing correction (9 tests).