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Table 4 Frequency of HIV/AIDS patients changing ART regimens within 3, 6 or 12 months post-initiation of treatment

From: PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients

Gene

ARV regimen or Genotype

Treatment initiation (n)

3 months

6 months

12 months

ARV regimen

 

3TC_TDF_EFV

9

0.11

0.11

0.22

 

AZT_3TC_EFV

11

0.00

0.09

0.27

 

d4T_3TC_EFV

222

0.03

0.08

0.22

NR1I2

     
 

rs3732356T/T

156

0.04

0.11

0.24

 

rs3732356T/G

117

0.03

0.06

0.21

 

rs3732356G/G

9

0.00

0.00

0.00*

 

rs2472677C/C

92

0.05

0.06

0.22

 

rs2472677C/T

128

0.02

0.11

0.23

 

rs2472677T/T

36

0.03

0.11

0.17

 

rs6785049G/G

251

0.03

0.08

0.22

 

rs6785049G/A

14

0.00

0.07

0.29

NR1I3

     
 

rs2307424C/C

257

0.02

0.07

0.21

 

rs2307424C/T

25

0.12

0.20

0.32

 

rs3003596T/T

96

0.04

0.08

0.23

 

rs3003596T/C

132

0.03

0.10

0.20

 

rs3003596C/C

52

0.02

0.06

0.23

 

rs2502815C/C

169

0.02

0.09

0.22

 

rs2502815C/T

98

0.05

0.08

0.22

 

rs2502815T/T

15

0.00

0.00

0.20

  1. *None of the subjects carrying the NR1I2 rs3732356G/G genotype changed their treatment regimen.