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Table 3 NR1I2 and NR1I3 genetic variants in 32 HIV/AIDS patients following targeted sequencing of the NR1I2 and NR1I3 DNA binding domains

From: PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients

SNP ID

Location/Functional effect

Minor allele

Minor allele n (freq)

NR1I2 rs12721601T>C

Previously reported, Intron 1

C

1 (0.016)

NR1I2 rs59371185G>A

Previously reported, Exon 2, Glu18Lys

A

1 (0.016)

NR1I2 rs12721613C>T

Previously reported, Exon 2, Pro27Ser

T

4 (0.064)

NR1I2 rs1464603C>T

Previously reported, Intron 2, Disrupts HNF1 TFB site

T

1 (0.016)

NR1I2 rs1464602C>T

Previously reported, Intron 2

T

20 (0.313)

NR1I2 rs80320762G>A

Previously reported, Intron 2

A

3 (0.048)

NR1I2 rs12721616C>T

Previously reported, Intron 2

T

14 (0.219)

NR1I2 rs112813596G>A

Previously reported, Intron 3

A

1 (0.016)

NR1I3 rs35205211C>G

Previously reported, Exon 4, Ala86Ala

G

2 (0.032)

NR1I3 rs34161743C>T

Previously reported, Exon 4, Arg97Trp

T

1 (0.016)

NR1I2 36726T>C

Novel, Intron 1

C

5 (0.078)

NR1I2 36857G>A*

Novel, Exon 2

A

1 (0.016)

NR1I2 36905C>T

Novel, Exon 2

T

2 (0.031)

  1. Position is noted according to the NR1I2 gene sequence [GenBank: AF364606], *Allele change according to the reverse sequence.