TY - JOUR AU - Swart, Marelize AU - Whitehorn, Heather AU - Ren, Yuan AU - Smith, Peter AU - Ramesar, Rajkumar S. AU - Dandara, Collet PY - 2012 DA - 2012/11/22 TI - PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients JO - BMC Medical Genetics SP - 112 VL - 13 IS - 1 AB - This study investigated variation in NR1I2 and NR1I3 and its effect on plasma efavirenz levels in HIV/AIDS patients. Variability in plasma drug levels has largely led research on identifying causative variants in drug metabolising enzyme (DME) genes, with little focus on the nuclear receptor genes NR1I2 and NR1I3, coding for PXR and CAR, respectively, that are involved in regulating DMEs. SN - 1471-2350 UR - https://doi.org/10.1186/1471-2350-13-112 DO - 10.1186/1471-2350-13-112 ID - Swart2012 ER -