Leukotriene B4 receptor locus gene characterisation and association studies in asthma

BMC Medical Genetics

Table 3 LTB4R SNP association analysis with asthma, FEV ₁ and BTS score 1 to 5 in 370 families

SNP no.*	SNP	Gene Location	Alleles	MAF		Asthma			FEV ₁			BTS (1–5)
					Fam	Z-score	P-value	Fam	Z-score	P-value	Fam	Z-score	P-value
	*LTB4R2*
1	rs2332320	5′UTR	T/C	0.096	116	−0.173	0.863	121	−0.350	0.726	118	−1.000	0.317
2	rs11158635	5′UTR	G/T	0.211	202	−0.648	0.517	211	−0.813	0.416	204	+0.386	0.699
3	rs2516564	5′UTR	C/T	0.212	215	−1.109	0.268	221	−1.288	0.198	218	−0.060	0.952
	*LTB4R1*
4	rs2224122	5′UTR	C/G	0.214	208	−0.907	0.365	217	−1.193	0.233	212	+0.103	0.918
5	rs1046587	3′UTR	G/A	0.494	282	−1.204	0.229	287	−1.391	0.164	287	−1.006	0.314
6	rs3181384	3′UTR	C/T	0.215	207	−0.895	0.371	215	−1.190	0.234	211	+0.157	0.875

The z score indicates the direction of the association (+ means the allele was overtransmitted = risk and – means undertransmitted = protection with respect to asthma affection; for continuous traits + indicates the allele confers higher trait values and – indicates the allele confers lower trait values). The z score is a measure of transmission equilibrium i.e. the deviation from the number of times an allele was transmitted to affected offspring and the number of times it should be transmitted under the null hypothesis of no association, no linkage. Number of families in analysis (≥10 families). *SNP location shown on Figure 1.

ISSN: 1471-2350