From: Leukotriene B4 receptor locus gene characterisation and association studies in asthma
Asthma Families | Adult Asthma Cohort | |||
---|---|---|---|---|
Pedigrees | Sibling 1 | Sibling 2 | ||
Age (years, mean±SD) | 26.2±1.6 | 13.3±4.4 | 10.3±4.6 | 39.24±12.31 |
Gender (%, Female) | 50.8 | 54.6 | 53.7 | 65.6 |
Asthma (%, Doctor diagnosed) | 61.6 | 100 | 100 | 100 |
FEV1 (% Predicted) (mean±SD) | ND | 95.4±15.6 | 96.2±14.9 | 92.37±20.57 |
Positive skin prick test (%) | 62.5 | 73.9 | 65.1 | 64.3 |
Eczema (%, questionnaire) | 41.1 | 53.5 | 55.1 | 31.8 |
Hay fever (%, questionnaire) | 50.2 | 64.9 | 47.4 | 64.5 |
Log total serum IgE (mean) | 2.04 | 2.33 | 2.33 | 2.03 |
Step on BTS guidelines (%): | ||||
· Step 1 | 19.1 | 24.9 | 23.8 | 13.7 |
· Step 2 | 32.5 | 52.7 | 55.7 | 17.7 |
· Step 3 | 6.1 | 11.6 | 10.2 | 50.9 |
· Step ≥4 | 4.7 | 9.2 | 6.7 | 17.7 |
n | 1578 | 370 | 361 | 299 |