Figure 1
From: Leukotriene B4 receptor locus gene characterisation and association studies in asthma
Schematic representation of the human LTB4R2 and LTB4R1 genes on chromosome 14 showing overlapping gene structure and polymorphic variation. Black boxes represent coding; LTB4R2 (left), LTB4R1 (right) and white boxes, non-coding exon sequence, space in-between represent intron. Data suggest LTB4R1/LTB4R2 expression can be directed by at least three different promoter regions 5′ to the marked TSS (underlined). Validated polymorphisms in Caucasians are shown; positions relative to the LTB4R1 ATG start codon (+1). SNPs numbered 1–6 correspond to genotyped SNPs in Table 3.