TY - JOUR AU - Tulah, Asif S. AU - Beghé, Bianca AU - Barton, Sheila J. AU - Holloway, John W. AU - Sayers, Ian PY - 2012 DA - 2012/11/20 TI - Leukotriene B4 receptor locus gene characterisation and association studies in asthma JO - BMC Medical Genetics SP - 110 VL - 13 IS - 1 AB - Polymorphisms spanning genes involved in the production of leukotriene B4 (LTB4) e.g. ALOX5AP and LTA4H are associated with asthma susceptibility, suggesting a role for LTB4 in disease. The contribution of LTB4receptor polymorphism is currently unknown. The aim of this study was to characterise the genes for the two pivotal LTB4 receptors, LTB4R1 and LTB4R2 in lung tissue and determine if polymorphisms spanning these genes are associated with asthma and disease severity. SN - 1471-2350 UR - https://doi.org/10.1186/1471-2350-13-110 DO - 10.1186/1471-2350-13-110 ID - Tulah2012 ER -