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Table 4 Relationships between increased number of risk alleles and T2DM

From: The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study

Quartiles of risk alleles

All subjects (n = 750)*

Obese/overweight (n = 243)**

Non-obese (n = 507)**

 

n

   

n

   

n

   
 

T2DM

Control

OR

(95% CI)

P -value

T2DM

Control

OR

(95% CI)

P -value

T2DM

Control

OR

(95% CI)

P -value

Q1

67

137

1

reference

 

36

25

1

reference

 

31

112

1

reference

 

(≦ 14)

               

Q2

93

130

1.42

(0.93-2.19)

0.11

43

26

1.15

(0.57-2.35)

0.69

50

104

1.71

(1.01-2.91)

0.045

(15, 16)

               

Q3

98

100

1.95

(1.27-2.99)

0.002

40

31

0.89

(0.44-1.79)

0.75

58

69

3.13

(1.85-5.41)

< 0.0001

(17, 18)

               

Q4

75

50

3.14

(1.93-5.14)

< 0.0001

30

12

1.77

(0.77-4.23)

0.18

45

38

4.20

(2.33-7.66)

< 0.0001

(≧ 19)

               
    

P for trend

< 0.0001

   

P for trend

0.88

   

P for trend

< 0.0001

  1. *ORs and P-values on T2DM for all subjects were adjusted with age and BMI
  2. **ORs and P-values on T2DM for obese/overweight and non-obese subjects were adjusted with age