The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study

Table 3 Multivariable regression analyses for T2DM

	Model 1			Model 2
R²	0.10			0.11
intercept	-10.43			-10.52
Determinant variables	β-coefficient	SE	P	β-coefficient	SE	P
No. of risk alleles	0.18	0.033	< 0.0001	0.18	0.033	< 0.0001
BMI	0.21	0.028	< 0.0001	0.22	0.029	< 0.0001
Age	0.04	0.014	0.0038	0.04	0.014	0.0036
BMI + No. of risk allele				-0.029	0.011	0.0080
	Model 3			Model 4
R²	0.089			0.097
intercept	-4.41			-1.11
Determinant variables	β-coefficient	SE	P	β-coefficient	SE	P
No. of risk alleles	0.18	0.032	< 0.0001	-0.026	0.11	0.81
Obesity/overweight	-1.22	0.20	< 0.0001	-1.19	0.22	< 0.0001
Age	0.04	0.014	0.0047	0.04	0.014	0.0047
Obesity/overweight + No. of risk allele				0.26	0.11	0.015

Model 1 included the number of risk alleles, BMI and age as covariates
Model 2 included the number of risk alleles, BMI, age and the interaction between the number of risk alleles and BMI as covariates
Model 3 included the number of risk alleles, obesity/overweight and age as covariates
Model 4 included the number of risk alleles, obesity/overweight, age and the interaction between the number of risk alleles and obesity/overweight as covariates
SE standard error

ISSN: 1471-2350