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Table 2 Individual effects of 17 risk alleles of the susceptibility loci on T2DM

From: The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study

   

Risk allele frequency

    

Locus

db SNP

Risk allele

T2DM

Control

OR

(95% CI)

P-value

Power

SLC30A8

rs13266634

C

0.64

0.57

1.95

(1.26-3.04)

0.0026

0.41

CDKN2A/B

rs10811661

A

0.61

0.54

1.96

(1.26-3.08)

0.0030

0.41

CDC123

rs11257622

C

0.26

0.21

1.99

(1.21-3.29)

0.0068

0.31

KCNQ1

rs2237892

C

0.64

0.58

1.85

(1.18-2.93)

0.0073

0.40

KCNJ11

rs5219

T

0.41

0.37

1.48

(0.96-2.28)

0.074

0.40

C2CD4A

rs7172432

A

0.59

0.54

1.48

(0.95-2.31)

0.081

0.41

IGF2BP2

rs4402960

T

0.34

0.30

1.45

(0.91-2.31)

0.12

0.37

CDKAL1

rs10946403

G

0.50

0.46

1.35

(0.88-2.08)

0.17

0.42

HNF1B

rs7501939

T

0.35

0.32

1.35

(0.85-2.14)

0.20

0.38

HHEX

rs1111875

G

0.30

0.28

1.25

(0.78-1.98)

0.35

0.36

UBE2E2

rs7612463

C

0.84

0.83

1.31

(0.73-2.36)

0.37

0.25

FTO

rs8050136

A

0.22

0.20

1.26

(0.73-2.15)

0.40

0.30

TCF7L2

rs7903146

T

0.06

0.05

1.39

(0.56-3.42)

0.48

0.12

PPARG

rs1801282

C

0.97

0.97

1.49

(0.44-5.34)

0.53

0.09

ADAMTS9

rs4607103

C

0.60

0.60

0.81

(0.52-1.25)

0.35

0.40

TSPAN8

rs7961581

C

0.19

0.19

0.95

(0.54-1.69)

0.87

0.29

JAZF1

rs864745

T

0.79

0.80

0.93

(0.55-1.57)

0.78

0.28

  1. Odd ratios and P-values were adjusted for age and BMI under the additive model
  2. Power to detect association was estimated under current sample size and minor allele frequency, assuming OR = 1.2
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BMC Medical Genetics

ISSN: 1471-2350

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