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Table 1 Anthropometric and metabolic characteristics of successfully genotyped glucose-tolerant Danish individuals from the Inter99 study according to rs1209523 FOXA2 genotype

From: The effect of FOXA2rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals

rs1209523 CC CT TT β [95%CI] p add
n (men/women) 4,091(1,880/2,211) 269(133/136) 8(6/2)   
Age (years) ¥ 45.2 ± 7.9 44.8 ± 7.3 45.7 ± 7.2   
BMI¥ 25.5 ± 4.1 25.5 ± 3.6 25.8 ± 2.4 -0.02 [-0.49; 0.45] 0.9
Plasma glucose (mmol/l)      
Fasting¥ 5.3 ± 0.4 5.3 ± 0.4 5.6 ± 0.3 -0.03 [-0.07; 0.01] 0.2
30-min during an OGTT¥ 8.2 ± 1.5 8.2 ± 1.5 8.9 ± 1.1 0.04 [-0.12; 0.21] 0.6
120-min during an OGTT¥ 5.5 ± 1.1 5.5 ± 1.1 5.3 ± 1.2 -0.02 [-0.14;0.11] 0.8
Incremental AUC¥ 181 ± 101 186 ± 98 185 ± 73 5.36 [-6.26; 16.98] 0.4
Serum insulin (pmol/l)      
Fasting 31 (22-45) 34 (23-49) 42 (30-50) 5.0% [-0.9; 10.8] 0.1
30-min during an OGTT 242 (175-344) 248 (188-346) 314 (232-425) 7.9% [2.1; 13.7] 0.008
120-min during an OGTT 136 (86-209) 137 (94-216) 212 (120-240) 9.3% [1.4; 17.3] 0.02
Incremental AUC 17,720 (12,540-25,020) 17,300 (13,680-25,800) 18,360 (14,250-28,120) 7.9% [1.6; 14.2] 0.01
Serum C-peptide (pmol/l)      
Fasting 493 (391-631) 520 (407-663) 602 (564-726) 3.8% [0.2; 7.5] 0.04
30-min during an OGTT 1,870 (1,470-2,360) 1,950 (1,580-2,412) 2,505 (1,685-2,738) 4.3% [0.4; 8.2] 0.03
120-min during an OGTT 1,960 (1,480-2,490) 1,990 (1,580-2,520) 2,485 (1,975-2,968) 5.0% [0.6; 9.3] 0.03
Incremental AUC 147,800 (117,200-183,200) 150,700 (122,700-185,400) 176,500 (150,000-199,400) 4.6% [0.7; 8.4] 0.02
Derived indices      
β-cell function      
Insulinogenic index 25.8 (17.9-37.6) 26.0 (19.6-39.0) 34.3 (19.7-42.4) 7.0% [0.5; 13.5] 0.03
BIGTT-AIR 1,672 (1,348-2,099) 1,710 (1,387-2,191) 1,455 (1,238-2,500) 3.5% [-1.1; 8.1] 0.1
HOMA-B 353 (248-508) 380 (267-560) 401 (310-488) 6.9% [0.9; 12.9] 0.02
AUCinsulin/AUCglucose 27.3 (20.2-37.4) 27.8 (21.1-39.7) 29.2 (23.2-40.8) 6.5% [1.2; 11.9] 0.02
Insulin sensitivity      
HOMA-IR 7.4 (5.2-10.9) 7.9 (5.4-11.8) 10.5 (7.8-11.8) 4.4% [-1.6; 10.4] 0.2
BIGTT-Si ¥ 10.4 ± 3.7 10.1 ± 3.7 8.6 ± 3.3 -0.33 [-0.78; 0.12] 0.2
ISIMatsuda 25.9 (18.2-35.6) 24.4 (16.8-34.5) 19.2 (15.0-26.5) -5.8% [-11.2; -0.4] 0.03
β-cell function corrected for insulin sensitivity      
Disposition index 3.5 (2.3-5.2) 3.7 (2.4-5.4) 3.9 (3.0-4.2) 2.6% [-4.9; 10.1] 0.5
  1. Data are unadjusted means ± SD¥ or medians (interquartile range). Values of serum insulin, serum c-peptide, and insulin-derived indices were logarithmically transformed prior to statistical analyses, and their effect sizes are presented as the increase/decrease in percent. Effect sizes (β) and p-values shown are for an additive genetic model and are adjusted for age, sex, and BMI where appropriate. CI, confidence interval; add, additive; AUC, area under the curve.