Table 2 Quantitative trait analyses of the effect of rs7072268 of HK1 among 5,604 non-diabetic individuals from the Inter99 study population

N (men/women)

1545 (765/780)

2757 (1347/1410)

1302 (644/658)

Age (years)

46.1 ± 8.0

45.8 ± 7.9

45.9 ± 7.7

Body composition

BMI (kg/m²)

25.9 ± 4.4

26.1 ± 4.4

26.0 ± 4.3

0.5

0.06 (-0.10; 0.22)

Waist-to-hip ratio

0.85 ± 0.08

0.85 ± 0.09

0.85 ± 0.09

0.2

0.001 (-0.001; 0.003)

Waist (cm)

86.7 ± 12.9

86.1 ± 12.8

85.8 ± 12.8

0.9

-0.12 (-0.20; 0.18)

Lipids

Triglycerides* (mmol/l)

1.0 (0.8; 1.4)

1.1 (0.8; 1.5)

1.1 (0.8; 1.5)

0.03

2.0 (0.2;3.8)

Cholesterol (mmol/l)

5.5 ± 1.0

5.5 ± 1.1

5.6 ± 1.1

0.001

0.06 (0.03; 1.0)

HDL cholesterol (mmol/l)

1.4 ± 0.4

1.4 ± 0.4

1.4 ± 0.4

0.7

0.003 (-0.010; 0.016)

LDL cholesterol (mmol/l)

3.5 ± 1.0

3.5 ± 0.9

3.6 ± 1.0

0.1

0.04 (-0.01; 0.09)

VLDL cholesterol (mmol/l)

0.6 ± 0.3

0.6 ± 0.3

0.6 ± 0.3

0.1

0.01 (-0.004; 0.03)

Serum Insulin

Fasting serum Insulin *

(pmol/l)

33.0 (23.0; 47.0)

34.0 (24.0; 51.0)

33.0 (23.0; 51.0)

0.2

1.2 (-0.7; 2.7)

Serum insulin 30 min *

(pmol/l)

242 (173; 355)

250 (179; 354)

244 (179; 359)

0.6

0.5 (-1.4; 2.4)

Serum insulin 120 min * (pmol/l)

151 (94.3; 242)

155 (96.0; 249)

148 (91.0; 248)

0.9

0.1 (-2.6; 2.9)

AUC insulin*

(pmol/l * min)

22460 (16200; 32620)

23490 (16950; 32770)

22820 (16770; 32910)

0.2

0.8 (-1.1; 2.6)

Plasma glucose

Fasting Plasma glucose (mmol/l)

5.4 ± 0.5

5.5 ± 0.5

5.5 ± 0.5

0.2

0.01 (-0.004; 0.03)

Plasma glucose 30 min (mmol/l)

8.5 ± 1.67

8.6 ± 1.7

8.6 ± 1.7

0.1

0.05 (-0.004; 0.1)

Plasma glucose 120 min (mmol/l)

5.9 ± 1.56

6.0 ± 1.5

6.0 ± 1.5

0.1

0.04 (-0.02; 0.09)

AUC glucose

(mmol/l* min)

856 ± 143

865 ± 145

866 ± 144

0.045

5.0 (0.1; 10.0)

Indices of insulin sensitivity

HOMA-IR*

7.8 (5.4; 11.6)

8.3 (5.7; 12.6)

7.9 (5.4; 12.8)

0.2

1.3 (-0.6; 3.3)

DI*

204 (140; 291)

194 (130; 279)

197 (129; 285)

0.3

-1.2 (-3.3; 0.9)

ISI*

8.3 (5.6; 9.5)

7.8 (5.3; 11.1)

8.0 (5.2; 11.6)

0.1

-1.4 (-3.2-0.4)

Indices of acute insulin response

Insulinolinogenic Index*

24.9 (17.3; 37.1)

25.1 (17.0; 37.3)

24.7 (17.4; 36.1)

0.8

0.4 (-1.8; 2.5)

Glycated haemoglobin levels

Hba1c* (%)

5.8 (5.5; 6.0)

5.8 (5.5; 6.1)

5.8 (5.6; 6.1)

3e-07

0.6 (0.4; 0.9)