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Figure 2 | BMC Medical Genetics

Figure 2

From: An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study

Figure 2

Genomic organization of the Nrf2 gene and linkage disequilibrium (LD) map for single-nucleotide polymorphisms (SNPs). Exons are shown as black boxes. Note that the reference sequence uses the complementary strand of DNA; thus, the 5' region is on the right. The 4 tag SNPs are located in the first intron and the 3 functional SNPs are in the promoter region. Pairwise LD values (r2 × 100) for the 4 tag SNPs and rs6721961 were calculated based on genotypes of the whole study population. The intensity of the gray shading in squares of the LD map is proportional to r2.

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