Skip to main content

Table 2 Association between a selected set of SNPs along the innate immunity-related inflammatory pathway and a number of metabolic phenotypes related to risk of type II diabetes mellitus.

From: Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes

  

Metabolic Markers1

  

Insulin2,3

Triglycerides2,4

HDL-C4

sCRP2,3

VDBP2

Gene

SNP (Proxy)

β ( p )

Model n

β ( p )

Model n

β ( p )

Model n

β ( p )

Model n

β ( p )

Model n

IL6

rs1554606

  

0.0574 (0.0103)

3,039

      
 

rs1474347 (rs7801406)

-0.155 (0.0078)

2,489

        

TNFA

rs3093662

0.316 (0.0034)

1,583

        
 

rs1800630 (rs2259435)

    

-0.0883 (0.0068)

1,945

    

CRP

rs1205 (rs2794520)

      

-0.498 (<0.0001)5

1,959

  
 

rs1417938 (rs12093699)

    

0.0699 (0.0079)

1,946

0.515 (<0.0001)5

1,951

0.0383 (0.0134)

1,082

  1. 1Values represent regression coefficient (β) and p-values in parentheses. Metabolic phenotypes and SNPs with no significant association were not presented. Bonferroni correction level of statistical significance is p < 0.0027; B-Y correction level of statistical significance is p < 0.014.
  2. 2Natural logarithm of measures.
  3. 3Adjusted for BMI, age and sex.
  4. 4Adjusted for BMI and sex.
  5. 5Associations remained significant (p < 0.05) after adjustment for other SNPs in the gene.
Back to article page

BMC Medical Genetics

ISSN: 1471-2350

Contact us