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Table 3 Significance and odds ratios of SNPs genotyped in the replication phase

From: Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotype

Gene SNP Minor allele and strand Logistic regression adjusted p value Genotypic association OR (95% CI) Heterozygous (Het) Homozygous minor (HM) Genotype Frequencies minor/het/major Cases (Ca) Pop. Controls (PC)
LOXL1 rs2304719 T/- 0.2 Het: 1.19 (0.90 - 1.57) Ca: 36/172/184
     HM: 1.51 (0.91 - 2.52) PC: 33/202/255
LOXL1 rs4461027 C/- 0.19 Het: 1.01 (0.76 - 1.36) Ca: 55/190/148
     HM: 0.72 (0.48 - 1.07) PC: 91/224/177
LOXL1 rs4886782 A/- 0.033 Het: 0.84 (0.63 - 1.11) Ca: 38/169/186
     HM: 0.56 (0.36 - 0.87) PC: 74/219/202
LOXL2 rs1002791 C/+ 0.61 Het: 1.05 (0.79 - 1.38) Ca: 31/155/207
     HM: 1.31 (0.77 - 2.22) PC: 31/192/268
LOXL2 rs17760913 T/- 0.94 Het: 1.04 (0.78 - 1.38) Ca: 25/148/217
     HM: 1.09 (0.62 - 1.91) PC: 35/189/266
LOXL2 rs17760943 A/- 0.86 Het: 0.96 (0.72 - 1.27) Ca: 25/139/229
     HM: 0.87 (0.50 - 1.49) PC: 29/171/293
LOXL2 rs2294125 G/+ 0.43 Het: 1.01 (0.74 - 1.37) Ca: 87/196/109
     HM: 1.25 (0.85 - 1.83) PC: 93/258/144
LOXL2 rs3808522 G/- 0.54 Het: 0.85 (0.63 - 1.16) Ca: 88/176/129
     HM: 0.97 (0.67 - 1.41) PC: 105/240/151
LOXL2 rs3808536 C/+ 0.92 Het: 1.01 (0.74 - 1.37) Ca: 82/188/123
     HM: 1.08 (0.74 - 1.57) PC: 98/239/157
LOXL2 rs6985160 T/- 0.16 Het: 0.77 (0.58 - 1.02) Ca: 50/165/178
     HM: 1.00 (0.65 - 1.55) PC: 56/239/200
LOXL2 rs6999447 T/- 0.31 Het: 1.25 (0.93 - 1.66) Ca: 54/184/155
     HM: 1.06 (0.71 - 1.60) PC: 71/206/217
LOXL4 rs11189510 A/+ 0.46 Het: 1.21 (0.88 - 1.65) Ca: 6/100/287
     HM: 1.34 (0.43 - 4.20) PC: 6/109/381
LOXL4 rs11189513 G/- 0.65 Het: 0.91 (0.69 - 1.21) Ca: 37/162/194
     HM: 0.82 (0.52 - 1.31) PC: 53/210/229
LOXL4 rs11599085 C/+ 0.08 Het: 0.74 (0.55 - 0.99) Ca: 54/160/178
     HM: 0.72 (0.48 - 1.08) PC: 79/227/186
  1. Adjusted p-value includes gender as a covariate. Because there were 14 SNPs assessed in this step, a Bonferroni correction would lead to significance with p < 0.004. The p-value displayed indicates the significance of the overall model and is adjusted for gender. The odds ratios use the homozygous major allele genotype as the reference genotype and genotype counts are presented for each group.