|
Gene
|
SNP
|
Minor allele and strand
|
Logistic regression adjusted p value
|
Genotypic association OR (95% CI) Heterozygous (Het) Homozygous minor (HM)
|
Genotype Frequencies minor/het/major Cases (Ca) Pop. Controls (PC)
|
|---|
|
LOXL1
|
rs2304719
|
T/-
|
0.2
|
Het: 1.19 (0.90 - 1.57)
|
Ca: 36/172/184
|
| | | | |
HM: 1.51 (0.91 - 2.52)
|
PC: 33/202/255
|
|
LOXL1
|
rs4461027
|
C/-
|
0.19
|
Het: 1.01 (0.76 - 1.36)
|
Ca: 55/190/148
|
| | | | |
HM: 0.72 (0.48 - 1.07)
|
PC: 91/224/177
|
|
LOXL1
|
rs4886782
|
A/-
|
0.033
|
Het: 0.84 (0.63 - 1.11)
|
Ca: 38/169/186
|
| | | | |
HM: 0.56 (0.36 - 0.87)
|
PC: 74/219/202
|
|
LOXL2
|
rs1002791
|
C/+
|
0.61
|
Het: 1.05 (0.79 - 1.38)
|
Ca: 31/155/207
|
| | | | |
HM: 1.31 (0.77 - 2.22)
|
PC: 31/192/268
|
|
LOXL2
|
rs17760913
|
T/-
|
0.94
|
Het: 1.04 (0.78 - 1.38)
|
Ca: 25/148/217
|
| | | | |
HM: 1.09 (0.62 - 1.91)
|
PC: 35/189/266
|
|
LOXL2
|
rs17760943
|
A/-
|
0.86
|
Het: 0.96 (0.72 - 1.27)
|
Ca: 25/139/229
|
| | | | |
HM: 0.87 (0.50 - 1.49)
|
PC: 29/171/293
|
|
LOXL2
|
rs2294125
|
G/+
|
0.43
|
Het: 1.01 (0.74 - 1.37)
|
Ca: 87/196/109
|
| | | | |
HM: 1.25 (0.85 - 1.83)
|
PC: 93/258/144
|
|
LOXL2
|
rs3808522
|
G/-
|
0.54
|
Het: 0.85 (0.63 - 1.16)
|
Ca: 88/176/129
|
| | | | |
HM: 0.97 (0.67 - 1.41)
|
PC: 105/240/151
|
|
LOXL2
|
rs3808536
|
C/+
|
0.92
|
Het: 1.01 (0.74 - 1.37)
|
Ca: 82/188/123
|
| | | | |
HM: 1.08 (0.74 - 1.57)
|
PC: 98/239/157
|
|
LOXL2
|
rs6985160
|
T/-
|
0.16
|
Het: 0.77 (0.58 - 1.02)
|
Ca: 50/165/178
|
| | | | |
HM: 1.00 (0.65 - 1.55)
|
PC: 56/239/200
|
|
LOXL2
|
rs6999447
|
T/-
|
0.31
|
Het: 1.25 (0.93 - 1.66)
|
Ca: 54/184/155
|
| | | | |
HM: 1.06 (0.71 - 1.60)
|
PC: 71/206/217
|
|
LOXL4
|
rs11189510
|
A/+
|
0.46
|
Het: 1.21 (0.88 - 1.65)
|
Ca: 6/100/287
|
| | | | |
HM: 1.34 (0.43 - 4.20)
|
PC: 6/109/381
|
|
LOXL4
|
rs11189513
|
G/-
|
0.65
|
Het: 0.91 (0.69 - 1.21)
|
Ca: 37/162/194
|
| | | | |
HM: 0.82 (0.52 - 1.31)
|
PC: 53/210/229
|
|
LOXL4
|
rs11599085
|
C/+
|
0.08
|
Het: 0.74 (0.55 - 0.99)
|
Ca: 54/160/178
|
| | | | |
HM: 0.72 (0.48 - 1.08)
|
PC: 79/227/186
|
- Adjusted p-value includes gender as a covariate. Because there were 14 SNPs assessed in this step, a Bonferroni correction would lead to significance with p < 0.004. The p-value displayed indicates the significance of the overall model and is adjusted for gender. The odds ratios use the homozygous major allele genotype as the reference genotype and genotype counts are presented for each group.
